LY 255283
Chemical Name: 1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]ethanone
Purity: ≥98%
Biological Activity
LY 255283 is a selective, competitive antagonist of BLT2 receptors (IC50 values are ~ 1 and > 10 μM at human recombinant BLT2 and BLT1 receptors respectively). Inhibits LTB4-induced contraction of lung parenchyma (pA2 = 7.2), and reduces LTB4-mediated airway obstruction in guinea pigs following i.v. and oral administration..Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Leukotriene B4 receptor antagonists: the LY255283 series of hydroxyacetophenones.
Herron et al.
J.Med.Chem., 1992;35:1818 -
Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist.
Silbaugh et al.
Eur.J.Pharmacol., 1992;223:57 -
Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2.
Yokomizo et al.
J.Biol.Chem., 2001;276:12454
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Citation for LY 255283
The citations listed below are publications that use Tocris products. Selected citations for LY 255283 include:
1 Citation: Showing 1 - 1
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Leukotriene D4-induced Caco-2 cell proliferation is mediated by prostaglandin E2 synthesis.
Authors: Cabral Et al.
PLoS One 2015;3
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