LY 2119620
Chemical Name: 3-Amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide
Purity: ≥98%
Biological Activity
LY 2119620 is a positive allosteric modulator of M2 and M4 muscarinic receptors. Potentiates activity of agonist at receptor in G protein-coupled functional assay. Cooperativity factor, α = 19.5 and 79.4 for M2 and M4 in presence of ACh, respectively. Binds in extracellular site.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M2 and M4 receptors.
Croy et al.
Mol.Pharmacol., 2014;86:106 -
Activation and allosteric modulation of a muscarinic acetylcholine receptor.
Kruse et al.
Nature, 2013;504:101
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