Lonidamine
Chemical Name: 1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid
Purity: ≥98%
Biological Activity
Lonidamine is an anticancer and antispermatogenic agent in vitro and in vivo. Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl- channels in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Effects of lonidamine on murine and human tumor cells in vitro. A morphological and biochemical study.
De Martino et al.
Oncology, 1984;41:15 -
Mechanism of lonidamine inhibition of the CFTR chloride channel.
Gong et al.
Br.J.Pharmacol., 2002;137:928 -
Lonidamine: in vitro/in vivo correlations.
Teiche
Eur.J.Cancer, 1994;30A:1411 -
Effects of lonidamine (AF 1890) and its analogues on follicle-stimulating hormone, luteinizing hormone, testost. and rat androgen binding protein concentrations in the rat and rhesus monkey.
Lobl et al.
Chemotherapy, 1981;27:61
Product Datasheets
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Citation for Lonidamine
The citations listed below are publications that use Tocris products. Selected citations for Lonidamine include:
1 Citation: Showing 1 - 1
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A mechanism for increased sensitivity of acute myeloid leukemia to mitotoxic drugs.
Authors: Panina Et al.
Cell Death Dis 2019;10:617
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