L-701,324

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. The atypical neuroleptic profile of the glycine/N-MthD.-aspartate receptor antagonist, L-701,324 in rodents.
   Bristow et al.
   J.Pharmacol.Exp.Ther., 1996;277:578
3. Anticonvulsant and behavioral profile of L-701,324, a potent, orally active antagonist at the glycine modulatory site on the N-MthD.-aspartate receptor complex.
   Bristow et al.
   J.Pharmacol.Exp.Ther., 1996;279:492
4. 3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: orally active antagonists of the glycine site on the NMDA receptor.
   Kulagowski et al.
   J.Med.Chem., 1994;37:1402
5. Inhibition of cortical spreading depression by L-701,324, a novel antagonist at the glycine site of the N-MthD.-aspartate receptor complex.
   Obrenovitch and Zilkha
   Br.J.Pharmacol., 1996;117:931

Product Datasheets