KB SRC 4

Catalog #: 4660
4 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
4660/10
4660/50

KB SRC 4 | CAS No. 1380088-03-8 | Src Family Kinase Inhibitors

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Description: Potent and selective c-Src inhibitor

Chemical Name: 1-[3-[1-([1,1'-Biphenyl]-3-ylmethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Purity: ≥98%

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Product Details

Citations (4)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

KB SRC 4 is a potent and selective c-Src inhibitor (K_i = 44 nM); does not inhibit c-Abl at concentrations up to 125 μM. Selective between Src family members (K_d values are 86, 160, 240, 720, 3200, 4400, and >40,000 nM for c-Src, Lck, Fgr, Yes, Lyn, Hck and Fyn respectively). Significantly inhibits cell growth in 4T1 mammary carcinoma tumor cells.

Technical Data

M.Wt:

555.03

Formula:

C₃₂H₂₃ClN₈

Solubility:

Soluble to 20 mM in DMSO

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

1380088-03-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Development of a highly selective c-Src kinase inhibitor.
Brandvold et al.
ACS Chem.Biol., 2012;7:1393

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for KB SRC 4

The citations listed below are publications that use Tocris products. Selected citations for KB SRC 4 include:

4 Citations: Showing 1 - 4

Biological characterization of ligands targeting the human CC chemokine receptor 8 (CCR8) reveals the biased signaling properties of small molecule agonists.
Authors: Dominique Et al.
Biochem Pharmacol 2021;188:114565
The NMDAR modulator NYX-2925 alleviates neuropathic pain via a Src-dependent mechanism in the mPFC.
Authors: Joseph R Et al.
Neurobiol Pain 2020;7:100039
Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE.
Authors: Carmona Et al.
Oncogene 2016;35:5155
An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin production.
Authors: Kim Et al.
Mol Cell Biol 2014;34:4368

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