K 114

Catalog # Availability Size / Price Qty
3144/10
3144/50
K 114 | CAS No. 872201-12-2 | Fluorescent Amyloid B Probes
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Description: Amyloid fibril-specific fluorescent probe. Used for: amyloid fibril detection. Application: fluorescence microscopy, confocal microscopy

Chemical Name: 4,4'-[(2-Bromo-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol

Purity: ≥98%

Product Details
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Biological Activity

Key information: K 114 is a potent amyloid fibril-specific fluorescent probe (EC50 = 20 - 30 nM).

Used for: amyloid fibril detection.

Application: fluorescence microscopy, confocal microscopy.

Properties and Photophysical Data: K 114 exhibits minimal fluorescence in aqueous buffers and fluoresces brightly in the presence of Aβ (1-40), α-synuclein and tau in situ. K 114 fluorescence is ph-dependent. Excitation and emission maxima (λ) are 370nm and 450 nm, respectively, at pH 8.5; excitation and emission maxima (λ) are 395nm and 520 nm, respectively, at pH 10.5.

Technical Data

M.Wt:
393.27
Formula:
C22H17BrO2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
872201-12-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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