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K 03861

Catalog #: 6789 Datasheet / COA / SDS
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K 03861 | CAS No. 853299-07-7 | Cyclin-dependent Kinase Inhibitors
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Description: Potent CDK2 inhibitor
Alternative Names: AUZ 454

Chemical Name: N-[4-[(2-Amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]urea

Purity: ≥98%

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Biological Activity

K 03861 is a potent Cdk2 inhibitor (Kd values are 9.7, 15.4, 18.6 and 50 nM at Cdk2 (C118L/A144C), Cdk2 (A144C), Cdk2 (C118L), and Cdk (WT) respectively. Competes with cyclin binding to inhibit Cdk2 kinase activity in vitro.

Technical Data

M.Wt:
501.51
Formula:
C24H26F3N7O2
Solubility:
Soluble to 50 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
853299-07-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. NEUROG1 regulates CDK2 to promote proliferation in otic progenitors
    Song et al.
    Stem Cell Reports, 2017;9:1516
  2. Type II inhibitors targeting Cdk2
    Alexander et al.
    ACS.Chem.Biol, 2015;10:2116

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