Home / BMP and Other Activin Receptor Inhibitors / K 02288

K 02288

Catalog #: 4986
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4986/10
4986/50
K 02288 | CAS No. 1431985-92-0 | BMP and Other Activin Receptor Inhibitors
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Description: Type 1 BMP receptor inhibitor
Alternative Names: K 02288a

Chemical Name: 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol

Purity: ≥99%

Product Details
Citations (3)
Supplemental Products
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

K 02288 is a potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC50 values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). Reduces BMP4-induced Smad1/5/8 phosphorylation in vitro (IC50 = 100 nM) and induces dorsalization of zebrafish embryos.

Technical Data

M.Wt:
352.38
Formula:
C20H20N2O4
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
1431985-92-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Development of an ALK2-biased BMP type I receptor kinase inhibitor.
    Mohedas et al.
    ACS Chem.Biol., 2013;8:1291
  2. A new class of small molecule inhibitor of BMP signaling.
    Sanvitale et al.
    PLoS ONE, 2013;8:62721

Product Datasheets

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Citations for K 02288

The citations listed below are publications that use Tocris products. Selected citations for K 02288 include:

3 Citations: Showing 1 - 3

  1. The mechanistic target of rapamycin pathway downregulates bone morphogenetic protein signaling to promote oligodendrocyte differentiation.
    Authors: Wendy B Et al.
    Glia  2020;68:1274-1290
  2. Transient exposure to androgens induces a remarkable self-sustained quiescent state in dispersed prostate cancer cells.
    Authors: Bui Et al.
    Cell Cycle  2017;16:879
  3. SMAD signaling and redox imbalance cooperate to induce prostate cancer cell dormancy.
    Authors: Bui Et al.
    Cell Cycle  2015;14:1218

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