(+)-JQ1 carboxylic acid
Chemical Name: (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid
Purity: ≥98%
Biological Activity
(+)-JQ1 carboxylic acid is a BET bromodomain inhibitor (+)-JQ1 (Cat. No. 4499) with a carboxylic acid functional group for conjugation reactions. Can be used as a precursor to PROTAC® Degraders that targets BET bromodomains after conjugation to a linker and E3 ligase ligand.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Selective small molecule induced degradation of the BET bromodomain protein BRD4.
Zengerle et al.
ACS Chem.Biol., 2015;10:1770 -
Structural basis of PROTAC cooperative recognition for selective protein degradation.
Gadd et al.
Nat.Chem.Biol., 2017; -
DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation.
Winter et al.
Science, 2015;348:1376
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