Home / Histamine H4 Receptor Antagonists / JNJ 39758979 dihydrochloride

JNJ 39758979 dihydrochloride

Catalog #: 6279 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6279/25
6279/5
JNJ 39758979 dihydrochloride | Histamine H4 Receptor Antagonists
1 Image
Description: High affinity and selective histamine H4 antagonist; orally bioavailable

Chemical Name: 4-[(3R)-3-Amino-1-pyrrolidinyl]-6-(1-methylethyl)-2-pyridinamine dihydrochloride

Purity: ≥98%

Product Details
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

JNJ 39758979 dihydrochloride is a high affinity and selective histamine H4 antagonist (Ki = 12.5 nM). Exhibits >80-fold selectivity for H4 over other histamine receptors and no significant activity at a range of other targets. Inhibits histamine-induced eosinophil shape change in whole blood in vitro and ovalbumin-induced inflammation in ovalbumin-sensitized mice in vivo. Orally bioavailable.

Technical Data

M.Wt:
294.22
Formula:
C11H19N5.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Janssen Pharmaceutica N.V.

Background References

  1. Clinical and preclinical characterization of the histamine H4 receptor antagonist JNJ-39758979.
    Thurmond et al.
    J.Pharmacol.Exp.Ther., 2014;349:176

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for JNJ 39758979 dihydrochloride

There are currently no reviews for this product. Be the first to review JNJ 39758979 dihydrochloride and earn rewards!

Have you used JNJ 39758979 dihydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.