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JH-II-127

Catalog #: 6289 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6289/50
6289/10
JH-II-127 | CAS No. 1700693-08-8 | LRRK2 Inhibitors
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Description: Potent and selective LRRK2 inhibitor

Chemical Name: [4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone

Purity: ≥98%

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Biological Activity

JH-II-127 is a potent and selective LRRK2 inhibitor (IC50 values are 2.2, 6.6 and 47.7 nM for G2019S-mutant, wild-type and A2016T-mutant LRRK2, respectively). Selective for LRRK2 over a panel of 138 kinases. Brain penetrant and orally bioavailable.

Technical Data

M.Wt:
416.87
Formula:
C19H21ClN6O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1700693-08-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute.

Product Datasheets

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