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Ionomycin calcium salt

Catalog #: 1704
17 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1704/1
Ionomycin calcium salt | CAS No. 56092-82-1 | Calcium Signaling Agents
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Description: Calcium ionophore

Chemical Name: (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoic acid calcium salt

Purity: ≥98%

Product Details
Citations (17)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Ionomycin calcium salt is a calcium ionophore; more specific than A23187.

Free Acid also available.

Technical Data

M.Wt:
747.08
Formula:
C41H70O9.Ca
Solubility:
Soluble to 100 mM in ethanol and to 25 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
56092-82-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Evidence that Ca2+ within the microdomain of the L-type voltage gated Ca2+ channel activates ERK in MIN6 cells in response to glucagon-like peptide-1.
    Selway J, Rigatti R, Storey N, Lu J, Willars GB, Herbert TP
    PLoS ONE, 2012;7(3):e33004.
  2. Characterization of ionomycin as a calcium ionophore.
    Liu and Hermann
    J.Biol.Chem., 1978;253:5892
  3. Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria.
    Kaufmann et al.
    J.Biol.Chem., 1980;255:2735
  4. Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils.
    Elzi et al.
    Am.J.Physiol.Cell Physiol., 2001;281:C350
  5. Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance
    Y Deng, X Xia, Y Zhao, Z Zhao, C Martinez, W Yin, J Yao, Q Hang, W Wu, J Zhang, Y Yu, W Xia, F Yao, D Zhao, Y Sun, H Ying, MC Hung, L Ma
    Nature Communications, 2021;12(1):7041.

Product Datasheets

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Citations for Ionomycin calcium salt

The citations listed below are publications that use Tocris products. Selected citations for Ionomycin calcium salt include:

17 Citations: Showing 1 - 10

  1. Overexpression of P2X4 receptor in Schwann cells promotes motor and sensory functional recovery and remyelination via BDNF secretion after nerve injury.
    Authors: Su Et al.
    Glia  2019;67:78
  2. Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations.
    Authors: Nieuwenhuijze Et al.
    Front Immunol  2018;9:2234
  3. Probing Internalization Effects and Biocompatibility of Ultrasmall Zirconium Metal-Organic Frameworks UiO-66 NP in U251 Glioblastoma Cancer Cells.
    Authors: Arcuri Et al.
    Nanomaterials (Basel)  2018;8
  4. Mechanically stimulated ATP release from murine bone cells is regulated by a balance of injury and repair.
    Authors: Mikolajewicz Et al.
    Elife  2018;7
  5. Involvement of VNUT-exocytosis in transient receptor potential vanilloid 4-dependent ATP release from gastrointestinal epithelium.
    Authors: Mihara Et al.
    PLoS One  2018;13:e0206276
  6. Hypotonic stress induces RANKL via transient receptor potential melastatin 3 (TRPM3) and vaniloid 4 (TRPV4) in human PDL cells.
    Authors: Son Et al.
    J Dent Res  2015;94:473
  7. Binding of αherpesvirus Glycoprotein H to Surface α4β1-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane.
    Authors: Azab Et al.
    PLoS One  2015;6
  8. Naturally Occurring Deletion Mutants of the Pig-Specific, Intestinal Crypt Epithelial Cell Protein CLCA4b without Apparent Phenotype.
    Authors: Plog Et al.
    PLoS One  2015;10:e0140050
  9. Assessment of TTX-s and TTX-r Action Potential Conduction along Neurites of NGF and GDNF Cultured Porcine DRG Somata.
    Authors: Jonas Et al.
    J Pharmacol Exp Ther  2015;10:e0139107
  10. TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis.
    Authors: Shambharkar Et al.
    MBio  2015;10:e0127480

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