Indatraline hydrochloride
Chemical Name: (1R,3S)-rel-3-(3,4-Dichlorophenyl)-2,3-dihydro-N-methyl-1H-inden-1-amine hydrochloride
Purity: ≥99%
Biological Activity
Indatraline hydrochloride is a potent monoamine uptake inhibitor. Inhibits transporters for 5-HT (SERT), dopamine (DAT) and noradrenaline (NET) (Ki values are 0.42, 1.7 and 5.8 nM respectively). Centrally active following systemic administration in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline.
Gu et al.
J.Med.Chem., 2000;43:4868 -
Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of DA, noradrenaline and serotonin.
Hyttel and Larsen
J.Neurochem., 1985;44:1615 -
Effects of the long-acting monoamine reuptake inhibitor indatraline on cocaine self-administration in rhesus monkeys.
Negus et al.
J.Pharmacol.Exp.Ther., 1999;291:60
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