Immepip dihydrobromide
Chemical Name: 4-(1H-Imidazol-4-ylmethyl)piperidine dihydrobromide
Biological Activity
Immepip dihydrobromide is a potent histamine H3 receptor agonist. Also binds to H4 receptors (Ki values are 0.4 and 9 nM at human recombinant H3 and H4 receptors respectively). Equipotent to or slightly more active than (R)-α-methylhistamine at H3 receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Cardiovascular effects of selective agonists and antagonists of histamine H3 receptors in the anaesthetized rat.
Coruzzi et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1995;351:569 -
Cloning and pharmacological characterization of a fourth histamine receptor (H4) expressed in bone marrow.
Liu et al.
Mol. Pharmacol., 2001;59:420 -
A new potent and selective histamine H3 receptor agonist.
Vollinga et al.
J.Med.Chem., 1994;37:332
Product Datasheets
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Citation for Immepip dihydrobromide
The citations listed below are publications that use Tocris products. Selected citations for Immepip dihydrobromide include:
1 Citation: Showing 1 - 1
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Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells.
Authors: Gründemann Et al.
Br J Pharmacol 2002;137:910
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