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IDE 1

Catalog #: 4015
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4015/10
4015/50
IDE 1 | CAS No. 1160927-48-9 | Compounds for Stem Cell Differentiation
1 Image
Description: Induces definitive endoderm formation in mouse and human ESCs

Chemical Name: 1-[2-[(2-Carboxyphenyl)methylene]hydrazide]heptanoic acid

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

IDE 1 is an induces definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC50 = 125 nM). Thought to activate the TGF-β signaling pathway; induces Smad2 phosphorylation and increases levels of Nodal expression.

This compound is mixture of E/Z isomers.

Technical Data

M.Wt:
306.31
Formula:
C15H18N2O5
Solubility:
Soluble to 100 mM in 2eq. NaOH and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1160927-48-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purpose under license from Harvard University.
Other Product-Specific Information:
  • This compound is mixture of E/Z isomers

Background References

  1. Using small molecules to great effect in stem cell differentiation.
    Zaret
    Cell Stem Cell, 2009;4:373
  2. Stimulation of AVNA/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells.
    Filby et al.
    Stem Cell Res.Ther., 2011;2:16
  3. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.
    Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA
    Cell Stem Cell, 2009-04-03;4(4):348-58.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

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Citations for IDE 1

The citations listed below are publications that use Tocris products. Selected citations for IDE 1 include:

3 Citations: Showing 1 - 3

  1. Differences in definitive endoderm induction approaches using growth factors and small molecules.
    Authors: Marjo Et al.
    J Cell Physiol  2018;233:3578-3589
  2. Rapid and high-efficiency generation of mature functional hepatocyte-like cells from adipose-derived stem cells by a three-step protocol.
    Authors: Xu Et al.
    Stem Cell Res  2015;6:193
  3. Generation of organized anterior foregut epithelia from pluripotent stem cells using small molecules.
    Authors: Kearns Et al.
    J Cell Mol Med  2013;11:1003

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