Hydroxy Dynasore
Chemical Name: 3-Hydroxynaphthalene-2-carboxylic acid 2-[(2,4,5)-trihydroxyphenyl)methylene]hydrazide
Purity: ≥98%
Biological Activity
Hydroxy Dynasore is a dynamin inhibitor (IC50 values are 0.38 and 2.6 μM for dynamin 1 and 2 respectively). Inhibits dynamin-mediated endocytosis in multiple cell types and reduces synaptic vesicle endocytosis in vitro. Prevents botulinum A internalization in hippocampal neurons. Also protects against botulinum A-induced muscle paralysis in rats. Analog of Dynasore (Cat. No. 2897).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism.
Harper et al.
J.Biol.Chem., 2011;286:35966 -
Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis.
McCluskey et al.
Traffic, 2013;14:1272
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