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Hydrocortisone

Catalog #: 4093
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4093/50
Hydrocortisone | CAS No. 50-23-7 | Glucocorticoid Receptor Compounds
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Description: Adrenal glucocorticoid; immunosuppressant

Chemical Name: 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Hydrocortisone is an adrenal glucocorticoid released in the stress response. Increases glucose production by gluconeogenesis. Immunosuppressant and antidiuretic hormone. Used in protocols to generate retinal pigment epithelial (RPE) cells from PSCs.

Technical Data

M.Wt:
362.46
Formula:
C21H30O5
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
50-23-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Enhancement of transfection efficiency with NLS and SPB-NLS.
    Lin, Jian, Qin, Tao, Zhu, Li Qi, Zhang, Qiang, Yu, Qing Hua, Yang, Qian
    Mol Med Rep, 2014;9(6):2559-67.
  2. Regulation of the CCL2 Gene in Pancreatic beta-Cells by IL-1beta and Glucocorticoids: Role of MKP-1.
    Burke S, Goff M, Updegraff B, Lu D, Brown P, Minkin S, Biggerstaff J, Zhao L, Karlstad M, Collier J
    PLoS ONE, 2012;7(10):e46986.
  3. Cortisol increases gluconeogenesis in humans; its role in the metabolic syndrome.
    Khani and Tayek
    Clin.Sci.(Lond), 2001;101:739

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Citations for Hydrocortisone

The citations listed below are publications that use Tocris products. Selected citations for Hydrocortisone include:

4 Citations: Showing 1 - 4

  1. Polyploid giant cancer cells, EZH2 and Myc upregulation in mammary epithelial cells infected with high-risk human cytomegalovirus.
    Authors: Georges Et al.
    EBioMedicine  2022;80:104056
  2. Cell Populations Expressing Stemness-Associated Markers in Lung Adenocarcinoma.
    Authors: Paul F Et al.
    Life (Basel)  2021;11
  3. Androgen receptor expression reduces stemness characteristics of prostate cancer cells (PC3) by repression of CD44 and SOX2.
    Authors: Srinivasan Et al.
    J Cell Biochem  2018;
  4. The Use of DQ-BSA to Monitor the Turnover of Autophagy-Associated Cargo.
    Authors: Frost Et al.
    Methods Enzymol  2017;587:43

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