HX 531
Chemical Name: 4-(7,8,9,10-Tetrahydro-5,7,7,10.10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]-diazepin-12-yl)-benzoic acid
Purity: ≥98%
Biological Activity
HX 531 is a potent RXR antagonist (IC50 = 18 nM). Promotes white and brown pre-adipocyte differentiation into white adipocytes. Also inhibits bexarotene-induced brown adipogenic reprogramming of myoblasts.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRgamma activation.
Leung W, Vong Q, Lin W, Janke L, Chen T, Leung W
J Exp Med, 2013;210(12):2675-92. -
Retinoid-X-receptors (alpha/beta) in melanocytes modulate innate immune responses and differentially regulate cell survival following UV irradiation.
Coleman D, Garcia G, Hyter S, Jang H, Chagani S, Liang X, Larue L, Ganguli-Indra G, Indra A
PLoS Genet, 2014;10(5):e1004321. -
Retinoid X receptor-antagonistic diazepinylbenzoic acids.
Ebisawa et al.
Chem.Pharm.Bull., 1999;47:1778 -
Vitamin A active metabolite, all-trans retinoic acid, induces spinal cord sensitization. II. Effects after intrathecal administration.
Alique et al.
Br.J.Pharmacol., 2006;149:65 -
Docosahexaenoic acid induces adipose differentiation-related protein through activation of retinoid X receptor in human choriocarcinoma BeWo cells.
Suzuki et al.
Biol.Pharm.Bull., 2009;32:1177 -
Brown adipogenic reprogramming induced by a small molecule.
Nie et al.
Cell Rep., 2017;18:624
Product Datasheets
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Citations for HX 531
The citations listed below are publications that use Tocris products. Selected citations for HX 531 include:
12 Citations: Showing 1 - 10
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Retinoic acid signaling is critical during the totipotency window in early mammalian development.
Authors: Ane Et al.
Nat Struct Mol Biol 2021;28:521-532
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Phenotypic landscape of intestinal organoid regeneration.
Authors: Rui Et al.
Nature 2020;586:275-280
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The novel rexinoid MSU-42011 is effective for the treatment of preclinical Kras-driven lung cancer.
Authors: Karen T Et al.
Sci Rep 2020;10:22244
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Assessment of total, ligand-induced peroxisome proliferator activated receptor γ ligand activity in serum.
Authors: Edwards Et al.
Environ Health 2019;18:45
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Toward Minimal Residual Disease-Directed Therapy in Melanoma.
Authors: Adriano Et al.
Cell 2018;174:843-855.e19
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Effects of electroacupuncture and the retinoid X receptor (RXR) signalling pathway on oligodendrocyte differentiation in the demyelinated spinal cord of rats.
Authors: Yang Et al.
Acupunct Med 2017;35:122
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Brown adipogenic reprogramming induced by a small molecule.
Authors: Nie Et al.
Cell.Rep. 2017;18:624
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Testicular organoid generation by a novel in vitro three-layer gradient system.
Authors: Olle Et al.
Biomaterials 2017;130:76-89
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Benzophenone-3 Impairs Autophagy, Alters Epigenetic Status, and Disrupts Retinoid X Receptor Signaling in Apoptotic Neuronal Cells.
Authors: Wnuk Et al.
Mol Neurobiol 2017;
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The Crucial Involvement of Retinoid X Receptors in DDE Neurotoxicity.
Authors: Wnuk Et al.
PLoS Biol 2016;29:155
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CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor.
Authors: Cherian Et al.
Mol Pharmacol 2015;87:878
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Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A.
Authors: Summermatter Et al.
Proc Natl Acad Sci U S A 2013;110:8738
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