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Human VEGFR1/Flt-1 Quantikine ELISA Kit

Catalog #: DVR100B
81 Citations Datasheet / COA / SDS
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Human VEGF R1/Flt-1 Standard Curve
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Product Details
Citations (81)
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Summary Precision Recovery Linearity Data Examples Product Datasheets Preparation and Storage Background Related Research Areas

Human VEGFR1/Flt-1 Quantikine ELISA Kit Summary

Assay Length
4.5 hours
Specificity
Natural and recombinant human soluble VEGF R1
Cross-reactivity
< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
Interference
No significant interference observed with available related molecules.

Product Summary

The Quantikine Human VEGF R1 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human soluble VEGF R1 in cell culture supernates, serum, plasma, saliva, and follicular fluid. It contains Sf 21-expressed recombinant human VEGF R1/Fc Chimera and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human VEGF R1 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring soluble VEGF R1.

Precision

Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision

Cell Culture Supernates, Serum, EDTA Plasma, Saliva, Follicular Fluid

Intra-Assay Precision Inter-Assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 20 20 20
Mean (pg/mL) 96.6 596 1213 112 645 1279
Standard Deviation 2.5 22.8 39.3 11 44.9 70.5
CV% 2.6 3.8 3.2 9.8 7 5.5

Recovery

The recovery of VEGF R1 spiked to levels throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Media (n=4) 100 86-113
EDTA Plasma (n=4) 99 89-105
Serum (n=4) 103 96-107

Linearity

To assess the linearity of the assay, samples containing and/or spiked with high concentrations of VEGF R1 were serially diluted with Calibrator Diluent to produce samples with values within the dynamic range of the assay.
Human VEGF R1/Flt-1 ELISA Linearity
Human VEGF R1/Flt-1 ELISA Linearity

Scientific Data

N/A Human VEGF R1/Flt-1 Standard Curve View Larger

Human VEGF R1/Flt-1 Standard Curve

N/A Human VEGF R1 Quantikine ELISA Kit Linearity Competitor Comparison View Larger

Human VEGF R1 Quantikine ELISA Kit Linearity Competitor Comparison

N/A Human VEGF R1 Quantikine ELISA Kit Sensitivity Competitor Comparison View Larger

Human VEGF R1 Quantikine ELISA Kit Sensitivity Competitor Comparison

N/A Human VEGF R1 Quantikine ELISA Kit Interference Competitor Comparison View Larger

Human VEGF R1 Quantikine ELISA Kit Interference Competitor Comparison

N/A Human VEGF R1/Flt-1 ELISA Standard Curve View Larger

Human VEGF R1/Flt-1 ELISA Standard Curve

Product Datasheets

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Product Datasheet
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Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: VEGFR1/Flt-1

VEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.

Long Name:
Vascular Endothelial Growth Factor Receptor 1
Entrez Gene IDs:
2321 (Human); 14254 (Mouse)
Alternate Names:
EC 2.7.10; EC 2.7.10.1; FLT; FLT1; Flt-1; Fms-like tyrosine kinase 1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascularpermeability factor receptor); FRT; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; vascular endothelial growth factor receptor 1; Vascular permeability factor receptor; VEGF R1; VEGFR1; VEGFR-1

Citations for Human VEGFR1/Flt-1 Quantikine ELISA Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

81 Citations: Showing 1 - 10
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  1. sFlt-1-enriched exosomes induced endothelial cell dysfunction and a preeclampsia-like phenotype in mice
    Authors: X Huang, L Jia, Y Jia, X Xu, R Wang, M Wei, H Li, H Peng, Y Wei, Q He, K Wang
    Cytokine, 2023-04-14;166(0):156190.
    Species: Human, Mouse
    Sample Types: Cell Culture Supernates, Serum
  2. Interaction between PD-L1 and soluble VEGFR1 in glioblastoma-educated macrophages
    Authors: X Liu, Z Li, J Sun, Z Zhang, W Li
    BMC Cancer, 2023-03-20;23(1):259.
    Species: Human
    Sample Types: Serum
  3. Alterations in Antioxidant Micronutrient Concentrations in Placental Tissue, Maternal Blood and Urine and the Fetal Circulation in Pre-eclampsia
    Authors: LO Kurlak, PJ Scaife, LV Briggs, F Broughton, DS Gardner, HD Mistry
    International Journal of Molecular Sciences, 2023-02-10;24(4):.
    Species: Human
    Sample Types: Plasma
  4. Similar Pro- and Antiangiogenic Profiles Close to Delivery in Different Clinical Presentations of Two Pregnancy Syndromes: Preeclampsia and Fetal Growth Restriction
    Authors: W Dymara-Kon, M Laskowska, E Grywalska, A Hymos, A B?a?ewicz, B Leszczy?sk
    International Journal of Molecular Sciences, 2023-01-04;24(2):.
    Species: Human
    Sample Types: Serum
  5. Cholecalciferol supplementation and angiogenic markers in chronic kidney disease
    Authors: J Kaur, K Kamboj, AK Yadav, P Kaur, V Kumar, V Jha
    PLoS ONE, 2022-06-03;17(6):e0268946.
    Species: Human
    Sample Types: Serum
  6. Placental lesions and differential expression of pro-and anti-angiogenic growth mediators and oxidative DNA damage marker in placentae of Ghanaian suboptimal and optimal health status pregnant women who later developed preeclampsia
    Authors: EO Anto, DA Coall, EA Asiamah, OO Afriyie, O Addai-Mens, YA Wiafe, W Owiredu, C Obirikoran, ME Annani-Ako, NA Titiloye, E Adua, E Acheampong, EA Adu, S Opoku, AO Anto, A Tawiah, Y Wang, W Wang
    PLoS ONE, 2022-03-21;17(3):e0265717.
    Species: Human
    Sample Types: Plasma
  7. Hematobiochemical variability and predictors of new-onset and persistent postpartum preeclampsia
    Authors: LA Fondjo, B Amoah, JJ Annan, EA Adu-Gyamfi, EA Asamaoh
    Scientific Reports, 2022-03-04;12(1):3583.
    Species: Human
    Sample Types: Serum
  8. Effect of Placenta-Derived Mesenchymal Stromal Cells Conditioned Media on an LPS-Induced Mouse Model of Preeclampsia
    Authors: AM Nuzzo, L Moretti, P Mele, T Todros, C Eva, A Rolfo
    International Journal of Molecular Sciences, 2022-01-31;23(3):.
    Species: Human
    Sample Types: Protein
  9. Impact of Chronic Kidney Disease on the Associations of Cardiovascular Biomarkers With Adverse Outcomes in Patients With Suspected or Known Coronary Artery Disease: The EXCEED-J Study
    Authors: H Wada, T Shinozaki, M Suzuki, S Sakagami, Y Ajiro, J Funada, M Matsuda, M Shimizu, T Takenaka, Y Morita, K Yonezawa, H Matsubara, Y Ono, T Nakamura, K Fujimoto, A Ninomiya, T Kato, T Unoki, D Takagi, K Wada, M Wada, M Iguchi, H Yamakage, T Kusakabe, A Yasoda, A Shimatsu, K Kotani, N Satoh-Asah, M Abe, M Akao, K Hasegawa, EXCEED?J S
    Journal of the American Heart Association, 2022-01-20;11(3):e023464.
    Species: Human
    Sample Types: Serum
  10. Spatial and temporal VEGF receptor intracellular trafficking in microvascular and macrovascular endothelial cells
    Authors: JAF Silva, X Qi, MB Grant, ME Boulton
    Scientific Reports, 2021-08-30;11(1):17400.
    Species: Human
    Sample Types: Nuclear Extract
  11. FGF-2 promotes angiogenesis through a SRSF1/SRSF3/SRPK1-dependent axis that controls VEGFR1 splicing in endothelial cells
    Authors: T Jia, T Jacquet, F Dalonneau, P Coudert, E Vaganay, C Exbrayat-H, J Vollaire, V Josserand, F Ruggiero, JL Coll, B Eymin
    Bmc Biology, 2021-08-25;19(1):173.
    Species: Human
    Sample Types: Cell Culture Supernates
  12. Circulating levels of angiogenic factors and their association with preeclampsia among pregnant women at Mulago National Referral Hospital in Uganda
    Authors: S Nabweyambo, OJ Sande, N McGovern, F Bwanga, A Ssekagiri, A Keesiga, M Adroma, R Wasswa, M Atuheirwe, J Namugenyi, B Castelnuov, A Nakimuli
    PLoS ONE, 2021-05-19;16(5):e0251227.
    Species: Human
    Sample Types: Plasma
  13. Circulating miRNAs Associated with Dysregulated Vascular and Trophoblast Function as Target-Based Diagnostic Biomarkers for Preeclampsia
    Authors: S Kim, M Park, JY Kim, T Kim, JY Hwang, KS Ha, MH Won, S Ryoo, YG Kwon, YM Kim
    Cells, 2020-08-31;9(9):.
    Species: Human
    Sample Types: Serum
  14. Divergent Impact of Breast Cancer Laterality on Clinicopathological, Angiogenic, and Hemostatic Profiles: A Potential Role of Tumor Localization in Future Outcomes
    Authors: RC Barbara, R Piotr, B Kornel, Z El?bieta, R Danuta, N Eduardo
    J Clin Med, 2020-06-02;9(6):.
    Species: Human
    Sample Types: Plasma
  15. Sleep-disordered breathing does not impact maternal outcomes in women with hypertensive disorders of pregnancy
    Authors: DL Wilson, ME Howard, AM Fung, FJ O'Donoghue, M Barnes, M Lappas, SP Walker
    PLoS ONE, 2020-04-27;15(4):e0232287.
    Species: Human
    Sample Types: Plasma
  16. Hydroxychloroquine Mitigates the Production of 8-Isoprostane and Improves Vascular Dysfunction: Implications for Treating Preeclampsia
    Authors: RA Rahman, P Murthi, H Singh, S Gurungsing, B Leaw, JC Mockler, R Lim, EM Wallace
    Int J Mol Sci, 2020-04-03;21(7):.
    Species: Human
    Sample Types: Placenta
  17. Diagnostic accuracy of sFlt1/PlGF ratio as a marker for preeclampsia
    Authors: P Nikuei, M Rajaei, N Roozbeh, F Mohseni, F Poordarvis, M Azad, S Haidari
    BMC Pregnancy Childbirth, 2020-02-07;20(1):80.
    Species: Human
    Sample Types: Serum
  18. Retina transduction by rAAV2 after intravitreal injection: comparison between mouse and rat
    Authors: MS Dias, VG Araujo, T Vasconcelo, Q Li, WW Hauswirth, R Linden, H Petrs-Silv
    Gene Ther., 2019-09-27;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  19. Systemic Inflammation Precedes Microalbuminuria in Diabetes
    Authors: FG Scurt, J Menne, S Brandt, A Bernhardt, PR Mertens, H Haller, C Chatzikyrk
    Kidney Int Rep, 2019-06-21;4(10):1373-1386.
    Species: Human
    Sample Types: Serum
  20. Anti-angiogenic efficacy in invasive breast carcinoma patients depends on clinicopathological determinants
    Authors: E Zarychta, P Rhone, K Bielawski, M Michalska, D Ro??, B Ruszkowska
    Adv Med Sci, 2019-02-26;64(2):216-223.
    Species: Human
    Sample Types: Plasma
  21. Sulphadoxine-pyrimethamine plus azithromycin may improve birth outcomes through impacts on inflammation and placental angiogenesis independent of malarial infection
    Authors: HW Unger, AP Hansa, C Buffet, W Hasang, A Teo, L Randall, M Ome-Kaius, S Karl, AA Anuan, JG Beeson, I Mueller, SJ Stock, SJ Rogerson
    Sci Rep, 2019-02-19;9(1):2260.
    Species: Human
    Sample Types: Plasma
  22. Angiogenic Properties of Menstrual Stem Cells Are Impaired in Women with a History of Preeclampsia
    Authors: M Varas-Godo, S Acuña-Gall, S Venegas-Du, C Hill, A Caceres-Ve, O Realini, LJ Monteiro, G Zavala, M Khoury, R Romero, G Rice, SE Illanes
    Stem Cells Int, 2019-01-27;2019(0):1916542.
    Species: Human
    Sample Types: Cell Culture Supernates
  23. A VEGF-A/SOX2/SRSF2 network controls VEGFR1 pre-mRNA alternative splicing in lung carcinoma cells
    Authors: C Abou Fayca, S Gazzeri, B Eymin
    Sci Rep, 2019-01-23;9(1):336.
    Species: Human
    Sample Types: Cell Culture Supernates
  24. ELABELA concentration is not decreased in maternal plasma before the onset of preeclampsia
    Authors: P Villie, G Lefevre, R Arrestier, A Rousseau, N Berkane, A Hertig
    Am. J. Obstet. Gynecol., 2018-12-18;220(3):284-285.
    Species: Human
    Sample Types: Plasma
  25. Intravitreal Injection of AAV Expressing Soluble VEGF Receptor-1 Variant Induces Anti-VEGF Activity and Suppresses Choroidal Neovascularization
    Authors: SHS Lee, HJ Kim, OK Shin, JS Choi, J Kim, YH Cho, J Ha, TK Park, JY Lee, K Park, H Lee
    Invest. Ophthalmol. Vis. Sci., 2018-11-01;59(13):5398-5407.
    Species: Human
    Sample Types: Cell Lysates
  26. Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice
    Authors: JA Sandgren, G Deng, DW Linggonego, SM Scroggins, KJ Perschbach, AR Nair, TE Nishimura, SY Zhang, LN Agbor, J Wu, HL Keen, MC Naber, NA Pearson, KA Zimmerman, RM Weiss, NC Bowdler, YM Usachev, DA Santillan, MJ Potthoff, GL Pierce, KN Gibson-Cor, CD Sigmund, MK Santillan, JL Grobe
    JCI Insight, 2018-10-04;3(19):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  27. Rationally designed AAV2 and AAVrh8R capsids provide improved transduction in the retina and brain
    Authors: JA Sullivan, LM Stanek, MJ Lukason, J Bu, SR Osmond, EA Barry, CR O'Riordan, LS Shihabuddi, SH Cheng, A Scaria
    Gene Ther., 2018-05-22;0(0):.
    Species: Mouse, Rabbit
    Sample Types: Tissue Homogenates, Vitreous Humor
  28. Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts
    Authors: GS Stødle, GB Silva, LH Tangerås, LM Gierman, I Nervik, UE Dahlberg, C Sun, MH Aune, LCV Thomsen, L Bjørge, AC Iversen
    Clin. Exp. Immunol., 2018-04-23;0(0):.
    Species: Human
    Sample Types: Serum
  29. Arginase controls soluble vascular endothelial growth factor receptor 1 (sFlt1) to maintain pregnancy homeostasis
    Authors: H Tanaka, K Kumasawa, A Kakigano, K Mimura, M Endo, T Tomimatsu, T Kimura
    Biochem. Biophys. Res. Commun., 2018-03-24;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  30. LIFR increases the release of sEng via the up-regulation of MMP14 expression in PE
    Authors: H Li, J Yao, X Chang, J Wu, T Duan, K Wang
    Reproduction, 2018-01-23;0(0):.
    Species: Human
    Sample Types: Plasma
  31. Corneal Mesenchymal Stromal Cells Are Directly Antiangiogenic via PEDF and sFLT-1
    Authors: M Eslani, I Putra, X Shen, J Hamouie, N Afsharkham, S Besharat, MI Rosenblatt, R Dana, P Hematti, AR Djalilian
    Invest. Ophthalmol. Vis. Sci., 2017-10-01;58(12):5507-5517.
    Species: Human
    Sample Types: Cell Culture Supernates
  32. Endothelial Dysfunction in Severe Preeclampsia is Mediated by Soluble Factors, Rather than Extracellular Vesicles
    Authors: M O'Brien, D Baczyk, JC Kingdom
    Sci Rep, 2017-07-19;7(1):5887.
    Species: Human
    Sample Types: Tissue Culture Supernates
  33. Household air pollution and angiogenic factors in pregnant Nigerian women: A randomized controlled ethanol cookstove intervention
    Authors: A Dutta, K Brito, G Khramstova, A Mueller, S Chinthala, D Alexander, D Adu, T Ibigbami, J Olamijulo, A Odetunde, K Adigun, L Pruitt, O Olopade, O Ojengbede, S Rana, CO Olopade
    Sci. Total Environ., 2017-05-29;599(0):2175-2181.
    Species: Human
    Sample Types: Plasma
  34. Synthetic Receptors Induce Anti Angiogenic and Stress Signaling on Human First Trimester Cytotrophoblast Cells
    Authors: AF Pantho, M Price, AZ Ashraf, U Wajid, ME Khansari, A Jahan, SH Afroze, MM Rhaman, CR Johnson, TJ Kuehl, MA Hossain, MN Uddin
    Int J Environ Res Public Health, 2017-05-11;14(5):.
    Species: Human
    Sample Types: Cell Culture Supernates
  35. The anti-angiogenic role of soluble-form VEGF receptor in malignant gliomas
    Authors: Shingo Takano
    Int. J. Oncol, 2016-12-19;0(0):.
    Species: Human
    Sample Types: Tissue Homogenates
  36. Low grade inflammation inhibits VEGF induced HUVECs migration in p53 dependent manner
    Authors: Sushil Panta
    Biochem. Biophys. Res. Commun, 2016-12-18;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  37. Spectrum of Factors Triggering Endothelial Dysfunction in PIH
    Authors: VS Jammalamad, P Abraham
    J Clin Diagn Res, 2016-12-01;10(12):BC14-BC17.
    Species: Human
    Sample Types: Serum
  38. Albuminuria Is Associated with Endothelial Dysfunction and Elevated Plasma Endothelin-1 in Sickle Cell Anemia
    PLoS ONE, 2016-09-26;11(9):e0162652.
    Species: Human
    Sample Types: Plasma
  39. Association between Placental Lesions, Cytokines and Angiogenic Factors in Pregnant Women with Preeclampsia
    Authors: Ingrid C Weel
    PLoS ONE, 2016-06-17;11(6):e0157584.
    Species: Human
    Sample Types: Tissue Homogenates
  40. Inhibition of placental growth factor in renal cell carcinoma.
    Authors: Bessho H, Wong B, Huang D, Siew E, Huang D, Tan J, Ong C, Tan S, Matsumoto K, Iwamura M, Teh B
    Anticancer Res, 2015-01-01;35(1):531-41.
    Species: Human
    Sample Types: Cell Culture Supernates
  41. Serum angiopoietin-2 and soluble VEGFR-2 levels predict malignancy of ovarian neoplasm and poor prognosis in epithelial ovarian cancer.
    Authors: Sallinen H, Heikura T, Koponen J, Kosma V, Heinonen S, Yla-Herttuala S, Anttila M
    BMC Cancer, 2014-09-23;14(0):696.
    Species: Human
    Sample Types: Serum
  42. FLT1 genetic variation predisposes to neovascular AMD in ethnically diverse populations and alters systemic FLT1 expression.
    Authors: Owen, Leah A, Morrison, Margaux, Ahn, Jeeyun, Woo, Se Joon, Sato, Hajime, Robinson, Rosann, Morgan, Denise J, Zacharaki, Fani, Simeonova, Marina, Uehara, Hironori, Chakravarthy, Usha, Hogg, Ruth E, Ambati, Balamura, Kotoula, Maria, Baehr, Wolfgang, Haider, Neena B, Silvestri, Giuliana, Miller, Joan W, Tsironi, Evangeli, Farrer, Lindsay, Kim, Ivana K, Park, Kyu Hyun, DeAngelis, Margaret
    Invest Ophthalmol Vis Sci, 2014-05-08;55(6):3543-54.
    Species: Human
    Sample Types: Serum
  43. Persistent urinary podocyte loss following preeclampsia may reflect subclinical renal injury.
    Authors: White W, Garrett A, Craici I, Wagner S, Fitz-Gibbon P, Butters K, Brost B, Rose C, Grande J, Garovic V
    PLoS ONE, 2014-03-24;9(3):e92693.
    Species: Human
    Sample Types: Serum
  44. Analysis of plasma cytokines and angiogenic factors in patients with pretreated urothelial cancer receiving Pazopanib: the role of circulating interleukin-8 to enhance the prognostic accuracy.
    Authors: Necchi A, Pennati M, Zaffaroni N, Landoni E, Giannatempo P, Raggi D, Schwartz L, Morosi C, Crippa F, Fare E, Nicolai N, Lanocita R, Sava T, Sacco C, Messina C, Ortega C, De Braud F, Salvioni R, Daidone M, Gianni A, Mariani L
    Br J Cancer, 2013-11-14;110(1):26-33.
    Species: Human
    Sample Types: Plasma
  45. Integrating multiple 'omics' analyses identifies serological protein biomarkers for preeclampsia.
    Authors: Liu, Linda Y, Yang, Ting, Ji, Jun, Wen, Qiaojun, Morgan, Alexande, Jin, Bo, Chen, Gongxing, Lyell, Deirdre, Stevenson, David K, Ling, Xuefeng, Butte, Atul J
    BMC Med, 2013-11-06;11(0):236.
    Species: Human
    Sample Types: Serum
  46. Placental growth factor and soluble Fms-like tyrosine kinase 1 in diabetic pregnancy: A possible relation to distal villous immaturity.
    Authors: El-Tarhouny S, Almasry S, Elfayomy A, Baghdadi H, Habib F
    Histol Histopathol, 2013-08-13;29(2):259-72.
    Species: Human
    Sample Types: Serum
  47. Fcgamma receptor-induced soluble vascular endothelial growth factor receptor-1 (VEGFR-1) production inhibits angiogenesis and enhances efficacy of anti-tumor antibodies.
    Authors: Justiniano S, Elavazhagan S, Fatehchand K, Shah P, Mehta P, Roda J, Mo X, Cheney C, Hertlein E, Eubank T, Marsh C, Muthusamy N, Butchar J, Byrd J, Tridandapani S
    J Biol Chem, 2013-07-31;288(37):26800-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  48. Advanced oxidation protein products enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts: a possible link between oxidative stress and preeclampsia.
    Authors: Huang Q, Wang S, Zhang M, Huang L, Tian J, Yu Y, Wang Z, Zhong M
    Placenta, 2013-07-27;34(10):949-52.
    Species: Human
    Sample Types: Cell Culture Supernates
  49. A randomized controlled trial of multicomponent exercise in older adults with mild cognitive impairment.
    Authors: Suzuki T, Shimada H, Makizako H, Doi T, Yoshida D, Ito K, Shimokata H, Washimi Y, Endo H, Kato T
    PLoS ONE, 2013-04-09;8(4):e61483.
    Species: Human
    Sample Types: Serum
  50. Role of serum concentration of VEGFR1 and TIMP2 on clinical outcome in primary cervical cancer: results of a companion protocol of the randomized, NOGGO-AGO phase III adjuvant trial of simultaneous cisplatin-based radiochemotherapy vs. carboplatin and paclitaxel containing sequential radiotherapy.
    Authors: Braicu E, Fotopoulou C, Chekerov R, Richter R, Blohmer J, Kummel S, Stamatian F, Yalcinkaya I, Mentze M, Lichtenegger W, Sehouli J
    Cytokine, 2013-02-14;61(3):755-8.
    Species: Human
    Sample Types: Serum
  51. Cardiac angiogenic imbalance leads to peripartum cardiomyopathy.
    Authors: Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, Hacker MR, Rhee JS, Mitchell J, Mahmood F, Hess P, Farrell C, Koulisis N, Khankin EV, Burke SD, Tudorache I, Bauersachs J, del Monte F, Hilfiker-Kleiner D, Karumanchi SA, Arany Z
    Nature, 2012-05-09;485(7398):333-8.
    Species: Human
    Sample Types: Plasma
  52. In vitro vascular tube formation testing as a tool for treatment individualisation in patients with cervical cancer.
    Authors: Landt S, Heidecke H, Korlach S, Reuter C, Schwidde I, Barinoff J, Thill M, Sehouli J, Kummel S
    Anticancer Res., 2011-08-01;31(8):2609-15.
    Species: Human
    Sample Types: Serum
  53. Prognostic significance of angiogenic factors in uterine cervical cancer.
    Authors: Landt S, Wehling M, Heidecke H, Jeschke S, Korlach S, Stoblen F, Schmid P, Blohmer JU, Lichtenegger W, Sehouli J, Kummel S
    Anticancer Res., 2011-08-01;31(8):2589-95.
    Species: Human
    Sample Types: Serum
  54. Expression and prognostic value of circulating angiogenic cytokines in pancreatic cancer.
    Authors: Rahbari NN, Schmidt T, Falk CS, Hinz U, Herber M, Bork U, Buchler MW, Weitz J, Koch M
    BMC Cancer, 2011-07-05;11(0):286.
    Species: Human
    Sample Types: Serum
  55. Phase I and pharmacokinetic study of sunitinib in pediatric patients with refractory solid tumors: a children's oncology group study.
    Authors: Dubois SG, Shusterman S, Ingle AM, Ahern CH, Reid JM, Wu B, Baruchel S, Glade-Bender J, Ivy P, Grier HE, Adamson PC, Blaney SM
    Clin. Cancer Res., 2011-06-20;17(15):5113-22.
    Species: Human
    Sample Types: Plasma
  56. Effect of smoking on circulating angiogenic factors in high risk pregnancies.
    Authors: Jeyabalan A, Powers RW, Clifton RG, Van Dorsten P, Hauth JC, Klebanoff MA, Lindheimer MD, Sibai B, Landon M, Miodovnik M, Caritis S, Roberts JM, Kuller J, Cotroneo M, Kamon T, Mercer B, Ramsey R, Paul R, Rabello Y, McCart D, Mueller E, Goldenberg R, Copper R, Sorokin Y, Norman G, Millinder A, Christmas JT, McCoy S, Elder S, Elder N, Carter B, Pemberton V, Thurnau G, Meier A, Minton V, Meis P, Swain M, Moawad AH, Jones P, Iams JD, Meadows S, Brenner S, Collins B, Newman RB, Carter SG, Romero R, Sabo V, Thom E, Bain RP, MacPherson C, Johnson D, Fischer ML, McNellis D, Spong C, Catz C, Yaffe S
    PLoS ONE, 2010-10-12;5(10):e13270.
    Species: Human
    Sample Types: Serum
  57. Soluble fms-Like tyrosine kinase 1 (sFlt1), endoglin and placental growth factor (PlGF) in preeclampsia among high risk pregnancies.
    Authors: Powers RW, Jeyabalan A, Clifton RG
    PLoS ONE, 2010-10-11;5(10):e13263.
    Species: Human
    Sample Types: Serum
  58. Periodic assessment of plasma sFlt-1 and PlGF concentrations and its association with placental morphometry in gestational hypertension (GH) - a prospective follow-up study.
    Authors: Jeevaratnam K, Nadarajah VD, Judson JP
    BMC Pregnancy Childbirth, 2010-09-28;10(0):58.
    Species: Human
    Sample Types: Plasma
  59. Soluble Flt-1 gene therapy ameliorates albuminuria but accelerates tubulointerstitial injury in diabetic mice.
    Authors: Kosugi T, Nakayama T, Li Q, Chiodo VA, Zhang L, Campbell-Thompson M, Grant M, Croker BP, Nakagawa T
    Am. J. Physiol. Renal Physiol., 2009-12-16;298(3):F609-16.
    Species: Human
    Sample Types: Urine
  60. Pre-eclampsia, soluble fms-like tyrosine kinase 1, and the risk of reduced thyroid function: nested case-control and population based study.
    Authors: Levine RJ, Vatten LJ, Horowitz GL
    BMJ, 2009-11-17;339(0):b4336.
    Species: Human
    Sample Types: Serum
  61. An automated method for the determination of the sFlt-1/PIGF ratio in the assessment of preeclampsia.
    Authors: Verlohren S, Galindo A, Schlembach D, Zeisler H, Herraiz I, Moertl MG, Pape J, Dudenhausen JW, Denk B, Stepan H
    Am. J. Obstet. Gynecol., 2009-10-21;202(2):161.e1-161.e1.
    Species: Human
    Sample Types: Serum
  62. Signs of reduced angiogenic activity after surgical removal of deeply infiltrating endometriosis.
    Authors: Bourlev V, Iljasova N, Adamyan L, Larsson A, Olovsson M
    Fertil. Steril., 2009-03-25;94(1):52-7.
    Species: Human
    Sample Types: Serum
  63. Are plasma VEGF and its soluble receptor sFlt-1 atherogenic risk factors? Cross-sectional data from the SAPHIR study.
    Authors: Sandhofer A, Tatarczyk T, Kirchmair R, Iglseder B, Paulweber B, Patsch JR, Schratzberger P
    Atherosclerosis, 2009-02-03;206(1):265-9.
    Species: Human
    Sample Types: Plasma
  64. Antiangiogenic gene therapy with soluble VEGFR-1, -2, and -3 reduces the growth of solid human ovarian carcinoma in mice.
    Authors: Sallinen H, Anttila M, Narvainen J, Koponen J, Hamalainen K, Kholova I, Heikura T, Toivanen P, Kosma VM, Heinonen S, Alitalo K, Yla-Herttuala S
    Mol. Ther., 2008-12-02;17(2):278-84.
    Species: Human
    Sample Types: Plasma
  65. Natural selection of FLT1 alleles and their association with malaria resistance in utero.
    Authors: Muehlenbachs A, Fried M, Lachowitzer J, Mutabingwa TK, Duffy PE
    Proc. Natl. Acad. Sci. U.S.A., 2008-09-08;105(38):14488-91.
    Species: Human
    Sample Types: Cell Culture Supernates, Plasma
  66. Plasma levels of soluble Tie2 and vascular endothelial growth factor distinguish critical limb ischemia from intermittent claudication in patients with peripheral arterial disease.
    Authors: Findley CM, Mitchell RG, Duscha BD, Annex BH, Kontos CD
    J. Am. Coll. Cardiol., 2008-07-29;52(5):387-93.
    Species: Human
    Sample Types: Plasma
  67. Cigarette smoke exposure and angiogenic factors in pregnancy and preeclampsia.
    Authors: Jeyabalan A, Powers RW, Durica AR, Harger GF, Roberts JM, Ness RB
    Am. J. Hypertens., 2008-06-19;21(8):943-7.
    Species: Human
    Sample Types: Plasma
  68. Regulation of vascular endothelial growth factor-A and its soluble receptor sFlt-1 by luteinizing hormone in vivo: implication for ovarian follicle angiogenesis.
    Authors: Gutman G, Barak V, Maslovitz S, Amit A, Lessing JB, Geva E
    Fertil. Steril., 2008-03-17;89(4):922-6.
    Species: Human
    Sample Types: Serum
  69. Angiogenesis markers (VEGF, soluble receptor of VEGF and angiopoietin-1) in very early arthritis and their association with inflammation and joint destruction.
    Authors: Clavel G, Bessis N, Lemeiter D, Fardellone P, Mejjad O, Menard JF, Pouplin S, Boumier P, Vittecoq O, Le Loet X, Boissier MC
    Clin. Immunol., 2007-06-08;124(2):158-64.
    Species: Human
    Sample Types: Serum
  70. Significant decrease in angiopoietin-1 and angiopoietin-2 after radical prostatectomy in prostate cancer patients.
    Authors: Caine GJ, Ryan P, Lip GY, Blann AD
    Cancer Lett., 2007-01-19;251(2):296-301.
    Species: Human
    Sample Types: Plasma
  71. Angiogenic growth factors in maternal and fetal serum in pregnancies complicated by intrauterine growth restriction.
    Authors: Wallner W, Sengenberger R, Strick R, Strissel PL, Meurer B, Beckmann MW, Schlembach D
    Clin. Sci., 2007-01-01;112(1):51-7.
    Species: Human
    Sample Types: Serum
  72. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia.
    Authors: Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, Sibai BM, Epstein FH, Romero R, Thadhani R, Karumanchi SA
    N. Engl. J. Med., 2006-09-07;355(10):992-1005.
    Species: Human
    Sample Types: Serum
  73. Changes in plasma vascular endothelial growth factor, angiopoietins, and their receptors following surgery for breast cancer.
    Authors: Caine GJ, Stonelake PS, Lip GY, Blann AD
    Cancer Lett., 2006-08-07;248(1):131-6.
    Species: Human
    Sample Types: Plasma
  74. Circulating angiogenic factors in preeclampsia, gestational proteinuria, and preeclampsia superimposed on chronic glomerulonephritis.
    Authors: Masuyama H, Suwaki N, Nakatsukasa H, Masumoto A, Tateishi Y, Hiramatrsu Y
    Am. J. Obstet. Gynecol., 2006-02-01;194(2):551-6.
    Species: Human
    Sample Types: Serum
  75. Phase I clinical and pharmacokinetic study of PTK/ZK, a multiple VEGF receptor inhibitor, in patients with liver metastases from solid tumours.
    Authors: Mross K, Drevs J, Muller M, Medinger M, Marme D, Hennig J, Morgan B, Lebwohl D, Masson E, Ho YY, Gunther C, Laurent D, Unger C
    Eur. J. Cancer, 2005-06-01;41(9):1291-9.
    Species: Human
    Sample Types: Serum
  76. Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia.
    Authors: Buhimschi CS, Norwitz ER, Funai E, Richman S, Guller S, Lockwood CJ, Buhimschi IA
    Am. J. Obstet. Gynecol., 2005-03-01;192(3):734-41.
    Species: Human
    Sample Types: Urine
  77. Hypoxia-induced increase in soluble Flt-1 production correlates with enhanced oxidative stress in trophoblast cells from the human placenta.
    Authors: Li H, Gu B, Zhang Y, Lewis DF, Wang Y
    Placenta, 2005-02-01;26(2):210-7.
    Species: Human
    Sample Types: Cell Culture Supernates
  78. Urinary placental growth factor and risk of preeclampsia.
    Authors: Levine RJ, Thadhani R, Qian C, Lam C, Lim KH, Yu KF, Blink AL, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA
    JAMA, 2005-01-05;293(1):77-85.
    Species: Human
    Sample Types: Urine
  79. GM-CSF induces expression of soluble VEGF receptor-1 from human monocytes and inhibits angiogenesis in mice.
    Authors: Eubank TD, Roberts R, Galloway M, Wang Y, Cohn DE, Marsh CB
    Immunity, 2004-12-01;21(6):831-42.
    Species: Human
    Sample Types: Cell Culture Supernates
  80. Circulating angiogenic factors and the risk of preeclampsia.
    Authors: Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA
    N. Engl. J. Med., 2004-02-05;350(7):672-83.
    Species: Human
    Sample Types: Serum
  81. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia.
    Authors: Maynard SE, Min JY, Merchan J, Lim KH, Mondal S, Stillman IE, Epstein FH, Karumanchi SA
    J. Clin. Invest., 2003-03-01;111(5):649-58.
    Species: Human
    Sample Types: Serum

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