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Human Transglutaminase 3/TGM3 (NP_003236.3) VersaClone cDNA

Catalog #: RDC3200 Datasheet / COA / SDS
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RDC3200
Human Transglutaminase 3/TGM3 (NP_003236.3) VersaClone cDNA
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Human Transglutaminase 3/TGM3 (NP_003236.3) VersaClone cDNA Summary

Specifications

Source
N/A
Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Human

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Background: Transglutaminase 3/TGM3

Transglutaminase 3 (TG3), also known as epidermal Transglutaminase (Tgase E), belongs to the family of Transglutaminase enzymes that catalyze the posttranslational modification of proteins via calcium dependent cross-linking reactions. TG3 is involved in the formation of the cornified envelope in skin keratinocytes. It functions to cross-link structural proteins during epidermal terminal differentiation. TG3 has been implicated as the dominant autoantigen in dermatitis herpetiformis. TG3 activation requires proteolysis of the 77 kDa zymogen into two fragments of approximately 50 and 27 kDa to form the active enzyme.

Entrez Gene IDs
7053 (Human); 21818 (Mouse)
Alternate Names
EC 2.3.2.13; MGC126250; protein-glutamine gamma-glutamyltransferase E; TG(E); TG3; TGase E; TGase-3; TgaseE; TGEMGC126249; TGM3; transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase); Transglutaminase 3; Transglutaminase E; transglutaminase-3

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