Home / TGF-beta RII / Human TGF-beta  RII PE-conjugated Antibody

Human TGF-beta  RII PE-conjugated Antibody

Catalog #: FAB241P
8 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
FAB241P-100
FAB241P-025
Detection of TGF-beta RII in NS0 Mouse Cell Line transfected with TGF-beta RII by Flow Cytometry.
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Citations (8)
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human TGF-beta  RII PE-conjugated Antibody Summary

Species Reactivity
Human
Specificity
This antibody has been validated by flow cytometry on TGF-beta RII-transfected cells only. In contrast to Catalog # FAB2411P, minimal staining of PBMC lymphocytes was observed with this antibody.
Source
Monoclonal Mouse IgG1 Clone # 25508
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human TGF-beta RII
Ile24-Asp159
Accession # P37173.2
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of TGF-beta RII antibody in NS0 Mouse Cell Line transfected with TGF-beta RII antibody by Flow Cytometry. View Larger

Detection of TGF-beta RII in NS0 Mouse Cell Line transfected with TGF-beta RII by Flow Cytometry. NS0 mouse myeloma cell line transfected with TGF-beta RII was stained with Mouse Anti-Human TGF-beta RII PE-conjugated Monoclonal Antibody (Catalog # FAB241P, filled histogram) or isotype control antibody (Catalog # IC002P, open histo-gram). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: TGF-beta RII

TGF-beta RII is a membrane bound serine/threonine kinase. Upon ligand binding, TGF-beta RII interacts with TGF-beta RI to form the heteromeric signaling complex that transduces TGF-beta signals. A splice variant of the type II receptor, TGF-beta RIIb, containing a 25 amino acid residue insertion near the N-terminus of the mature protein has also been described.

Long Name
Transforming Growth Factor beta Receptor II
Entrez Gene IDs
7048 (Human); 21813 (Mouse)
Alternate Names
AAT3; EC 2.7.11; EC 2.7.11.30; FAA3; HNPCC6; LDS1B; LDS2B; MFS2; RIIC; TAAD2; tbetaR-II; TGF-beta receptor type II; TGF-beta receptor type IIB; TGF-beta receptor type-2; TGF-beta RII; TGF-beta type II receptor; TGFbetaRII; TGFbeta-RII; TGFBR2; TGF-bRII; TGFR-2; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II (70/80kDa) isoform 1; transforming growth factor, beta receptor II (70/80kDa) isoform 2; transforming growth factor, beta receptor II (70/80kDa); transforming growth factor, beta receptor II (70-80kD); Transforming growth factor-beta receptor type II

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Citations for Human TGF-beta  RII PE-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

8 Citations: Showing 1 - 8
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  1. Feline glycoprotein A repetitions predominant anchors transforming growth factor beta on the surface of activated CD4(+)CD25(+) regulatory T cells and mediates AIDS lentivirus-induced T cell immunodeficiency
    Authors: Michelle M. Miller, Jonathan E. Fogle, Peter Ross, Mary B. Tompkins
    AIDS Research and Human Retroviruses
  2. Dupuytren's Disease Is Mediated by Insufficient TGF-?1 Release and Degradation
    Authors: Oezel, L;Wohltmann, M;Gondorf, N;Wille, J;Güven, I;Windolf, J;Thelen, S;Jaekel, C;Grotheer, V;
    International journal of molecular sciences
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  3. Quiescent innate and adaptive immune responses maintain the long-term integrity of corneal endothelium reconstituted through allogeneic cell injection therapy
    Authors: M Toda, M Ueno, J Yamada, A Hiraga, K Asada, J Hamuro, C Sotozono, S Kinoshita
    Scientific Reports, 2022-10-27;12(1):18072.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  4. Reparative effect of mesenchymal stromal cells on endothelial cells after hypoxic and inflammatory injury
    Authors: JM Sierra-Par, A Merino, M Eijken, H Leuvenink, R Ploeg, BK Møller, B Jespersen, CC Baan, MJ Hoogduijn
    Stem Cell Res Ther, 2020-08-12;11(1):352.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry, Immunophenotyping
  5. Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells
    Authors: S Stephenson, MA Care, I Fan, A Zougman, DR Westhead, GM Doody, RM Tooze
    J. Immunol., 2019-01-14;202(4):1287-1300.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  6. CD4+CD25+ T regulatory cells activated during feline immunodeficiency virus infection convert T helper cells into functional suppressors through a membrane-bound TGFbeta / GARP-mediated mechanism.
    Authors: Miller M, Petty C, Tompkins M, Fogle J
    Virol J, 2014-01-18;11(0):7.
    Species: Feline
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  7. Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation.
    Authors: Lages CS, Suffia I, Velilla PA, Huang B, Warshaw G, Hildeman DA, Belkaid Y, Chougnet C
    J. Immunol., 2008-08-01;181(3):1835-48.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  8. Chronic exposure to asbestos enhances TGF-beta 1 production in the human adult T cell leukemia virus-immortalized T cell line MT-2
    Authors: MEGUMI MAEDA, YING CHEN, HIROAKI HAYASHI, NAOKO KUMAGAI-TAKEI, HIDENORI MATSUZAKI, SUNI LEE et al.
    International Journal of Oncology

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