Human RAGE Quantikine ELISA Kit Summary
Product Summary
Precision
Cell Culture Supernates
Intra-Assay Precision | Inter-Assay Precision | |||||
---|---|---|---|---|---|---|
Sample | 1 | 2 | 3 | 1 | 2 | 3 |
n | 20 | 20 | 20 | 40 | 40 | 40 |
Mean (pg/mL) | 571 | 1549 | 3189 | 563 | 1568 | 3159 |
Standard Deviation | 34 | 73 | 191 | 49 | 110 | 193 |
CV% | 5.9 | 4.7 | 6 | 8.7 | 7 | 6.1 |
Serum, EDTA Plasma, Heparin Plasma
Intra-Assay Precision | Inter-Assay Precision | |||||
---|---|---|---|---|---|---|
Sample | 1 | 2 | 3 | 1 | 2 | 3 |
n | 20 | 20 | 20 | 40 | 40 | 40 |
Mean (pg/mL) | 546 | 1527 | 3117 | 519 | 1449 | 2890 |
Standard Deviation | 34 | 73 | 189 | 43 | 119 | 192 |
CV% | 6.2 | 4.8 | 6.1 | 8.2 | 8.2 | 6.7 |
Recovery
The recovery of RAGE spiked to levels throughout the range of the assay was evaluated.
Sample Type | Average % Recovery | Range % |
---|---|---|
Tissue Culture Media (n=4) | 98 | 86-108 |
Linearity
Scientific Data
Product Datasheets
Preparation and Storage
Background: RAGE/AGER
RAGE (Receptor for Advanced Glycation End product) is a transmembrane glycoprotein that binds advanced glycation end products (AGEs), beta-amyloid peptides, HMGB1/Amphoterin, and several S100 family proteins. AGEs are adducts formed by the non-enzymatic glycation and oxidation of proteins and lipids. A soluble form can also be generated by MMP-mediated shedding. RAGE is expressed in the CNS during development as well as in adult endothelial cells, smooth muscle cells, pericytes, monocytes, and neurons. It is locally upregulated in vascular inflammation (e.g. diabetes, atherosclerosis, vascular injury, Alzheimer’s disease). At these sites, RAGE binding to S100A1, EN-RAGE/S100A12, or S100B induces inflammatory immune cell adhesion and infiltration as well as vascular smooth muscle proliferation, neointimal expansion, atherosclerotic plaque development, and transport of A-beta into the cerebrospinal fluid. In cancer, RAGE binding to HMGB1, S100A8, or S100A9 promotes tumor growth and metastasis in addition to inflammatory cell infiltration.
To view our complete solutions for RAGE research, visit bio-techne.com.
Assay Procedure
Refer to the product- Prepare all reagents, standard dilutions, and samples as directed in the product insert.
- Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.
- Add 100 µL of Assay Diluent to each well.
- Add 50 µL of Standard, control, or sample to each well. Cover with a plate sealer, and incubate at room temperature for 2 hours.
- Aspirate each well and wash, repeating the process 3 times for a total of 4 washes.
- Add 200 µL of Conjugate to each well. Cover with a new plate sealer, and incubate at room temperature for 2 hours.
- Aspirate and wash 4 times.
- Add 200 µL Substrate Solution to each well. Incubate at room temperature for 30 minutes. PROTECT FROM LIGHT.
- Add 50 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.
Citations for Human RAGE Quantikine ELISA Kit
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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RAGE in circulating immune cells is fundamental for hippocampal inflammation and cognitive decline in a mouse model of latent chronic inflammation
Authors: Ye, D;Miyoshi, A;Ushitani, T;Kadoya, M;Igeta, M;Konishi, K;Shoji, T;Yasuda, K;Kitaoka, S;Yagi, H;Kuroda, E;Yamamoto, Y;Cheng, J;Koyama, H;
Brain, behavior, and immunity
Species: Transgenic Mouse
Sample Types: Serum
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Effects of acute aerobic exercise on circulating sTLR and sRAGE profiles in normal- and abnormal-glucose-tolerant individuals
Authors: Perkins, RK;Miranda, ER;Varshney, P;Farabi, SS;Quinn, LT;Haus, JM;
Physiological reports
Species: Human
Sample Types: Plasma
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Immunogenic Biomarkers HMGB1 and sRAGE Are Potential Diagnostic Tools for Ovarian Malignancies
Authors: Schröder, L;Rupp, ABA;Gihr, KME;Kobilay, M;Domroese, CM;Mallmann, MR;Holdenrieder, S;
Cancers
Species: Human
Sample Types: Serum
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Assessing Pulmonary Epithelial Damage in Hantavirus Cardiopulmonary Syndrome: Challenging the Predominant Role of Vascular Endothelium through sRAGE as a Potential Biomarker
Authors: Meza-Fuentes, G;López, R;Vial, C;Cortes, LJ;Retamal, MA;Delgado, I;Vial, P;
Viruses
Species: Human
Sample Types: Plasma
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Effectiveness of two photosensitizer-mediated photodynamic therapy for treating moderate peri-implant infections in type-II diabetes mellitus patients: A randomized clinical trial
Authors: Elsadek, MF;
Photodiagnosis and photodynamic therapy
Species: Human
Sample Types: Complex Sample Type
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Apoptotic Cell Death in Bicuspid-Aortic-Valve-Associated Aortopathy
Authors: SJ Barnard, J Haunschild, L Heiser, MT Dieterlen, K Klaeske, MA Borger, CD Etz
International Journal of Molecular Sciences, 2023-04-18;24(8):.
Species: Human
Sample Types: Tissue Homogenates
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Genetically Modified Circulating Levels of Advanced Glycation End-Products and Their Soluble Receptor (AGEs-RAGE Axis) with Risk and Mortality of Breast Cancer
Authors: Y Peng, F Liu, Y Qiao, P Wang, H Du, C Si, X Wang, K Chen, F Song
Cancers, 2022-12-12;14(24):.
Species: Human
Sample Types: Plasma
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High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasone
Authors: L Butcher, JC Zaldua, JA Carnicero, K Hawkins, J Whitley, R Mothukuri, PA Evans, K Morris, S Pillai, JD Erusalimsk
Respiratory Research, 2022-11-05;23(1):303.
Species: Human
Sample Types: Serum
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Advanced Glycation End Product (AGE) and Soluble Receptor of AGE (sRAGE) Levels in Relation to Periodontitis Severity and as Putative 3-Year Outcome Predictors in Patients Undergoing Coronary Artery Bypass Grafting (CABG)
Authors: S Reichert, B Hofmann, M Kohnert, AN Santos, L Friebe, J Grollmitz, HG Schaller, S Schulz
Journal of Clinical Medicine, 2022-07-15;11(14):.
Species: Human
Sample Types: Serum
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SCD14-ST and New Generation Inflammatory Biomarkers in the Prediction of COVID-19 Outcome
Authors: E Galliera, L Massaccesi, L Yu, J He, M Ranucci, MM Corsi Roma
Biomolecules, 2022-06-13;12(6):.
Species: Human
Sample Types: Plasma
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Significantly Altered Serum Levels of NAD, AGE, RAGE, CRP, and Elastin as Potential Biomarkers of Psoriasis and Aging-A Case-Control Study
Authors: A Karas, D Holmannova, P Borsky, Z Fiala, C Andrys, K Hamakova, T Svadlakova, V Palicka, J Krejsek, V Rehacek, M Esterkova, H Kovarikova, L Borska
Biomedicines, 2022-05-13;10(5):.
Species: Human
Sample Types: Serum
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RAGE has potential pathogenetic and prognostic value in nonintubated hospitalized patients with COVID-19
Authors: KD Wick, L Siegel, JD Neaton, C Oldmixon, J Lundgren, RL Dewar, HC Lane, BT Thompson, MA Matthay, ACTIV-3/TI
JCI Insight, 2022-05-09;7(9):.
Species: Human
Sample Types: Plasma
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Plasma Levels of Free N?-Carboxymethyllysine (CML) after Different Oral Doses of CML in Rats and after the Intake of Different Breakfasts in Humans: Postprandial Plasma Level of sRAGE in Humans
Authors: C Helou, MT Nogueira S, C Niquet-Ler, P Jacolot, E Boulanger, F Delguste, A Guilbaud, M Genin, PM Anton, C Delayre-Or, T Papazian, M Howsam, FJ Tessier
Nutrients, 2022-04-30;14(9):.
Species: Human
Sample Types: Plasma
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Association between plasma sRAGE and emphysema according to the genotypes of AGER gene
Authors: S Sin, MN Lim, J Kim, SH Bak, WJ Kim
BMC pulmonary medicine, 2022-02-10;22(1):58.
Species: Human
Sample Types: Plasma
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Differential Regulation of Circulating Soluble Receptor for Advanced Glycation End Products (sRAGEs) and Its Ligands S100A8/A9 Four Weeks Post an Exercise Intervention in a Cohort of Young Army Recruits
Authors: IA Drosatos, JN Tsoporis, S Izhar, S Gupta, G Tsirebolos, E Sakadakis, AS Triantafyl, A Rigopoulos, D Rigopoulos, LS Rallidis, I Rizos, TG Parker
Biomolecules, 2021-09-13;11(9):.
Species: Human
Sample Types: Plasma
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Soluble Receptor for Advanced Glycation End Products (sRAGE) Is a Sensitive Biomarker in Human Pulmonary Arterial Hypertension
Authors: F Diekmann, P Chouvarine, H Sallmon, L Meyer-Kobb, M Kieslich, BD Plouffe, SK Murthy, R Lichtingha, E Legchenko, G Hansmann
International Journal of Molecular Sciences, 2021-08-10;22(16):.
Species: Human
Sample Types: Plasma
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Cellular Response against Oxidative Stress, a Novel Insight into Lupus Nephritis Pathogenesis
Authors: CD Ene, SR Georgescu, M Tampa, C Matei, CI Mitran, MI Mitran, MN Penescu, I Nicolae
Journal of personalized medicine, 2021-07-22;11(8):.
Species: Human
Sample Types: Serum
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Leptin and advanced glycation end products receptor (RAGE) in tuberculosis patients
Authors: TK Lazzari, E Cavalheiro, SE Coutinho, LF da Silva, DR Silva
PLoS ONE, 2021-07-02;16(7):e0254198.
Species: Human
Sample Types: Serum
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SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care
Authors: C Gutmann, K Takov, SA Burnap, B Singh, H Ali, K Theofilato, E Reed, M Hasman, A Nabeebaccu, M Fish, MJ McPhail, K O'Gallaghe, LE Schmidt, C Cassel, M Rienks, X Yin, G Auzinger, S Napoli, SF Mujib, F Trovato, B Sanderson, B Merrick, U Niazi, M Saqi, K Dimitrakop, R Fernández-, S Braun, R Kronstein-, KJ Doores, JD Edgeworth, AM Shah, SR Bornstein, T Tonn, AC Hayday, M Giacca, M Shankar-Ha, M Mayr
Nature Communications, 2021-06-07;12(1):3406.
Species: Human
Sample Types: Plasma
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Changes in Plasma Soluble Receptor for Advanced Glycation End-Products Are Associated with Survival in Patients with Acute Respiratory Distress Syndrome
Authors: M Jabaudon, B Pereira, E Laroche, L Roszyk, R Blondonnet, J Audard, T Godet, E Futier, JE Bazin, V Sapin, JA Bastarache, LB Ware, JM Constantin, On Behalf
Journal of Clinical Medicine, 2021-05-12;10(10):.
Species: Human
Sample Types: Plasma
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Posttranslational Modifications Pattern in Clear Cell Renal Cell Carcinoma
Authors: CD Ene, MN Penescu, SR Georgescu, M Tampa, I Nicolae
Metabolites, 2020-12-27;11(1):.
Species: Human
Sample Types: Serum
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Circulating soluble receptor for advanced glycation end products and other factors in type 2 diabetes patients with colorectal cancer
Authors: X Zhou, N Lin, M Zhang, X Wang, Y An, Q Su, P Du, B Li, H Chen
BMC Endocr Disord, 2020-11-13;20(1):170.
Species: Human
Sample Types: Serum
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G82S RAGE polymorphism influences amyloid-RAGE interactions relevant in Alzheimer's disease pathology
Authors: RC C, B Lukose, P Rani
PLoS ONE, 2020-10-29;15(10):e0225487.
Species: Human
Sample Types: Cell Lysates
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RAGE Up-Regulation Differently Affects Cell Proliferation and Migration in Pancreatic Cancer Cells
Authors: P Swami, S Thiyagaraj, A Vidger, VSK Indurthi, SW Vetter, E Leclerc
Int J Mol Sci, 2020-10-19;21(20):.
Species: Human
Sample Types: Cell Lysates
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Circulating antibodies against age-modified proteins in patients with coronary atherosclerosis
Authors: E Korça, V Piskovatsk, J Börgermann, A Navarrete, A Simm
Sci Rep, 2020-10-13;10(1):17105.
Species: Human
Sample Types: Plasma
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Circulating Receptor Activator of Nuclear Factor kB Ligand and triglycerides are associated with progression of lower limb arterial calcification in type 2 diabetes: a prospective, observational cohort study
Authors: O Bourron, F Phan, MH Diallo, D Hajage, CE Aubert, A Carlier, JE Salem, C Funck-Bren, S Kemel, P Cluzel, A Redheuil, JM Davaine, Z Massy, R Mentaverri, D Bonnefont-, P Gillery, S Jaisson, C Vermeer, JM Lacorte, N Bouziri, S Laroche, C Amouyal, A Hartemann
Cardiovascular Diabetology, 2020-09-18;19(1):140.
Species: Human
Sample Types: Plasma
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Collagen methionine sulfoxide and glucuronidine/LW-1 are markers of coronary artery disease in long-term survivors with type 1 diabetes. The Dialong study
Authors: KB Holte, M Svanteson, KF Hanssen, KA Sveen, I Seljeflot, S Solheim, DR Sell, VM Monnier, TJ Berg
PLoS ONE, 2020-05-13;15(5):e0233174.
Species: Human
Sample Types: Serum
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Biomarkers of Cellular Stress Do Not Associate with sCD14 in Progressive HIV and SIV Infections in Vivo
Authors: CL Vinton, CE Starke, AM Ortiz, SH Lai, JK Flynn, O Sortino, K Knox, I Sereti, JM Brenchley
Pathog Immun, 2020-04-24;5(1):68-88.
Species: Human
Sample Types: Plasma
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Association between advanced glycation end products, their soluble receptor, and mortality in the general population: Results from the CARLA study
Authors: H Ebert, ME Lacruz, A Kluttig, A Simm, KH Greiser, D Tiller, N Kartschmit, R Mikolajczy
Exp. Gerontol., 2019-12-16;131(0):110815.
Species: Human
Sample Types: Plasma
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Systemic RAGE ligands are upregulated in tuberculosis individuals with diabetes co-morbidity and modulated by anti-tuberculosis treatment and metformin therapy
Authors: NP Kumar, K Moideen, A Nancy, V Viswanatha, BS Shruthi, S Sivakumar, S Hissar, H Kornfeld, S Babu
BMC Infect. Dis., 2019-12-09;19(1):1039.
Species: Human
Sample Types: Plasma
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Advanced glycation end products and their ratio to soluble receptor are associated with limitations in physical functioning only in women: results from the CARLA cohort
Authors: H Ebert, ME Lacruz, A Kluttig, A Simm, KH Greiser, D Tiller, N Kartschmit, R Mikolajczy
BMC Geriatr, 2019-11-04;19(1):299.
Species: Human
Sample Types: Plasma
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Soluble receptor for advanced glycation end-products independently influences individual age-dependent increase of arterial stiffness
Authors: J Gelžinský, O Mayer, J Seidlerová, M Mate?ánkov, Š Mareš, V Kordíková, L Trefil, R Cífková, J Filipovský
Hypertens. Res., 2019-10-21;0(0):.
Species: Human
Sample Types: Serum
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Systemic Inflammation Precedes Microalbuminuria in Diabetes
Authors: FG Scurt, J Menne, S Brandt, A Bernhardt, PR Mertens, H Haller, C Chatzikyrk
Kidney Int Rep, 2019-06-21;4(10):1373-1386.
Species: Human
Sample Types: Serum
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The Effect of 600 mg Alpha-lipoic Acid Supplementation on Oxidative Stress, Inflammation, and RAGE in Older Adults with Type 2 Diabetes Mellitus
Authors: VM Mendoza-Nú, BI García-Mar, J Rosado-Pér, E Santiago-O, J Pedraza-Ch, VJ Hernández-
Oxid Med Cell Longev, 2019-06-12;2019(0):3276958.
Species: Human
Sample Types: Plasma
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Expression of the receptor of advanced glycation end-products (RAGE) and membranal location in peripheral blood mononuclear cells (PBMC) in obesity and insulin resistance
Authors: EDC Ruelas Cin, B Ruíz Madri, JA Domínguez, M Maldonado, L De la Cruz, SM Ramírez Me, JR Torres Bar, E Martínez L, ZH Hernández
Iran J Basic Med Sci, 2019-06-01;22(6):623-630.
Species: Human
Sample Types: Serum
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Metabolic dysfunction in Emirati subjects in Abu Dhabi: Relationship to levels of soluble RAGEs
Authors: A Abdulle, CK Inman, A Saleh, M Noshi, D Galani, L Abdelwaret, H Alsafar, A Elfatih, H Al Shamsi, R Ali, H Li, R Ramasamy, AM Schmidt, MM Benbarka, MH Hassan
J Clin Transl Endocrinol, 2019-04-23;16(0):100192.
Species: Human
Sample Types: Plasma
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Advanced glycation end products (AGE) and receptor for AGE (RAGE) in patients with active tuberculosis, and their relationship between food intake and nutritional status
Authors: LF da Silva, EC Skupien, TK Lazzari, SR Holler, EGC de Almeida, LR Zampieri, SE Coutinho, M Andrades, DR Silva
PLoS ONE, 2019-03-14;14(3):e0213991.
Species: Human
Sample Types: Plasma
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The rationale and design of the personal diet study, a randomized clinical trial evaluating a personalized approach to weight loss in individuals with pre-diabetes and early-stage type 2 diabetes
Authors: CJ Popp, DE St-Jules, L Hu, L Ganguzza, P Illiano, M Curran, H Li, A Schoenthal, M Bergman, AM Schmidt, E Segal, A Godneva, MA Sevick
Contemp Clin Trials, 2019-03-04;0(0):.
Species: Human
Sample Types:
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sRAGE and early signs of cardiac target organ damage in mild hypertensives
Authors: AM Maresca, L Guasti, S Bozzini, C Mongiardi, N Tandurella, R Corso, FG Zerba, A Squizzato, L Campiotti, F Dentali, C Klersy, AM Grandi, C Falcone
Cardiovasc Diabetol, 2019-02-12;18(1):17.
Species: Human
Sample Types: Plasma
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The ratio of AGE to sRAGE independently associated with albuminuria in hypertensive patients
Authors: KH Chiang, JW Chen, SS Huang, HB Leu, SJ Lin, PH Huang
BMC Endocr Disord, 2018-11-13;18(1):84.
Species: Human
Sample Types: Plasma
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Serum AGE/RAGEs as potential biomarker in idiopathic pulmonary fibrosis
Authors: C Machahua, A Montes-Wor, L Planas-Cer, R Buendia-Fl, M Molina-Mol, V Vicens-Zyg
Respir. Res., 2018-11-08;19(1):215.
Species: Human
Sample Types: Serum
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Quantification of the soluble Receptor of Advanced Glycation End-Products (sRAGE) by LC-MS after enrichment by strong cation exchange (SCX) solid-phase extraction (SPE) at the protein level
Authors: F Klont, MR Joosten, NHT Ten Hacken, P Horvatovic, R Bischoff
Anal. Chim. Acta, 2018-09-29;1043(0):45-51.
Species: Human
Sample Types: Serum
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A prospective study of soluble receptor for advanced glycation end products and adipokines in association with pancreatic cancer in postmenopausal women
Authors: DL White, RC Hoogeveen, L Chen, P Richardson, M Ravishanka, P Shah, L Tinker, T Rohan, EA Whitsel, HB El-Serag, L Jiao
Cancer Med, 2018-03-23;0(0):.
Species: Human
Sample Types: Serum
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TGF?1 reinforces arterial aging in the vascular smooth muscle cell through a long-range regulation of the cytoskeletal stiffness
Authors: W Zhu, BC Kim, M Wang, J Huang, A Isak, NM Bexiga, R Monticone, T Ha, EG Lakatta, SS An
Sci Rep, 2018-02-08;8(1):2668.
Species: Human
Sample Types: Plasma
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Receptor for advanced glycation end-products and ARDS prediction: a multicentre observational study
Authors: M Jabaudon, P Berthelin, T Pranal, L Roszyk, T Godet, JS Faure, R Chabanne, N Eisenmann, A Lautrette, C Belville, R Blondonnet, S Cayot, T Gillart, J Pascal, Y Skrzypczak, B Souweine, L Blanchon, V Sapin, B Pereira, JM Constantin
Sci Rep, 2018-02-08;8(1):2603.
Species: Human
Sample Types: Plasma
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Elevations of novel cytokines in bacterial meningitis in infants
Authors: L Srinivasan, L Kilpatrick, SS Shah, S Abbasi, MC Harris
PLoS ONE, 2018-02-02;13(2):e0181449.
Species: Human
Sample Types: CSF
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Evolution and bad prognostic value of advanced glycation end products after acute heart failure: relation with body composition
Authors: B Paradela-D, Á Fernández-, D Bou-Teen, S Eiras, R González-F, RM Agra, A Varela-Rom, AI Castro-Pai, MC Carreira, FF Casanueva, E Álvarez, JR González-J
Cardiovasc Diabetol, 2017-09-15;16(1):115.
Species: Human
Sample Types: Plasma
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Club cell protein 16 and cytokeratin fragment 21-1 as early predictors of pulmonary complications in polytraumatized patients with severe chest trauma
Authors: LL Negrin, G Halat, S Kettner, M Gregori, R Ristl, S Hajdu, T Heinz
PLoS ONE, 2017-04-05;12(4):e0175303.
Species: Human
Sample Types: Serum
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Decreased levels of sRAGE in follicular fluid from patients with PCOS
Authors: BiJun Wang
Reproduction, 2016-12-13;0(0):.
Species: Human
Sample Types: Aspirated Follicle Fluid
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The Initial Months of Antiretroviral Therapy and Its Influence on AGEs, HMGB1, and sRAGE Levels in Asymptomatic HIV-Infected Individuals
Authors: Karen Ingrid Tasca
Mediators Inflamm, 2016-11-30;2016(0):2909576.
Species: Human
Sample Types: Plasma
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Innovative Flow Cytometry Allows Accurate Identification of Rare Circulating Cells Involved in Endothelial Dysfunction
PLoS ONE, 2016-08-25;11(8):e0160153.
Species: Human
Sample Types: Plasma
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Soluble RAGE and atherosclerosis in youth with type 1 diabetes: a 5-year follow-up study.
Authors: Heier M, Margeirsdottir H, Gaarder M, Stensaeth K, Brunborg C, Torjesen P, Seljeflot I, Hanssen K, Dahl-Jorgensen K
Cardiovasc Diabetol, 2015-09-25;14(1):126.
Species: Human
Sample Types: Serum
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Serum Level of Soluble Receptor for Advanced Glycation End Products Is Associated with A Disintegrin And Metalloproteinase 10 in Type 1 Diabetes.
Authors: Lee A, Lam J, Shiu S, Wong Y, Betteridge D, Tan K
PLoS ONE, 2015-09-01;10(9):e0137330.
Species: Human
Sample Types: Serum
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Soluble Forms and Ligands of the Receptor for Advanced Glycation End-Products in Patients with Acute Respiratory Distress Syndrome: An Observational Prospective Study.
Authors: Jabaudon M, Blondonnet R, Roszyk L, Pereira B, Guerin R, Perbet S, Cayot S, Bouvier D, Blanchon L, Sapin V, Constantin J
PLoS ONE, 2015-08-14;10(8):e0135857.
Species: Human
Sample Types: Serum
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The impact of concomitant pulmonary infection on immune dysregulation in Pneumocystis jirovecii pneumonia.
Authors: Chou C, Lin F, Tsai H, Chang S
BMC Pulm Med, 2014-11-19;14(0):182.
Species: Human
Sample Types: BALF
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Local and systemic RAGE axis changes in pulmonary hypertension: CTEPH and iPAH.
Authors: Moser B, Megerle A, Bekos C, Janik S, Szerafin T, Birner P, Schiefer A, Mildner M, Lang I, Skoro-Sajer N, Sadushi-Kolici R, Taghavi S, Klepetko W, Ankersmit H
PLoS ONE, 2014-09-04;9(9):e106440.
Species: Human
Sample Types: Serum
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Higher serum soluble receptor for advanced glycation end product levels and lower prevalence of metabolic syndrome among Japanese adult men: a cross-sectional study.
Authors: Momma H, Niu K, Kobayashi Y, Huang C, Chujo M, Otomo A, Tadaura H, Miyata T, Nagatomi R
Diabetol Metab Syndr, 2014-03-06;6(1):33.
Species: Human
Sample Types: Serum
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GeneOptimizer program-assisted cDNA reengineering enhances sRAGE autologous expression in Chinese hamster ovary cells.
Authors: Wei, Wen, Kim, Ji Min, Medina, Danny, Lakatta, Edward G, Lin, Li
Protein Expr Purif, 2013-12-25;95(0):143-8.
Species: Chinese Hamster
Sample Types: Cell Culture Supernates
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Placental growth factor, pregnancy-associated plasma protein-A, soluble receptor for advanced glycation end products, extracellular newly identified receptor for receptor for advanced glycation end products binding protein and high mobility group box 1 levels in patients with acute kidney injury: a cross sectional study.
Authors: Zakiyanov O, Kriha V, Vachek J, Zima T, Tesar V, Kalousova M
BMC Nephrol, 2013-11-04;14(0):245.
Species: Human
Sample Types: Serum
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Diastolic dysfunction of aging is independent of myocardial structure but associated with plasma advanced glycation end-product levels.
Authors: Campbell D, Somaratne J, Jenkins A, Prior D, Yii M, Kenny J, Newcomb A, Schalkwijk C, Black M, Kelly D
PLoS ONE, 2012-11-26;7(11):e49813.
Species: Human
Sample Types: Plasma
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The soluble form of the receptor of advanced glycation endproducts increases after bariatric surgery in morbid obesity.
Authors: Brix J, Hollerl F, Kopp H, Schernthaner G, Schernthaner G
Int J Obes (Lond), 2012-07-17;36(11):1412-7.
Species: Human
Sample Types: Serum
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Methodological and Preanalytical Evaluation of a RAGE Immunoassay.
Authors: Wittwer C, Lehner J, Fersching D, Siegele B, Stoetzer OJ, Holdenrieder S
Anticancer Res., 2012-05-01;32(5):2075-8.
Species: Human
Sample Types: Serum
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Soluble RAGE as a severity marker in community acquired pneumonia associated sepsis.
Authors: Narvaez-Rivera RM, Rendon A, Salinas-Carmona MC
BMC Infect. Dis., 2012-01-20;12(0):15.
Species: Human
Sample Types: Serum
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Total soluble and endogenous secretory receptor for advanced glycation end products as predictive biomarkers of coronary heart disease risk in patients with type 2 diabetes: an analysis from the CARDS trial.
Authors: Colhoun HM, Betteridge DJ, Durrington P, Hitman G, Neil A, Livingstone S, Charlton-Menys V, Bao W, Demicco DA, Preston GM, Deshmukh H, Tan K, Fuller JH
Diabetes, 2011-07-19;60(9):2379-85.
Species: Human
Sample Types: Serum
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Soluble form of the receptor for advanced glycation end products is a marker of acute lung injury but not of severe sepsis in critically ill patients.
Authors: Jabaudon M, Futier E, Roszyk L
Crit. Care Med., 2011-03-01;39(3):480-8.
Species: Human
Sample Types: Plasma
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Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells.
Authors: Yamakawa N, Uchida T, Matthay MA, Makita K
Am. J. Physiol. Lung Cell Mol. Physiol., 2011-01-21;300(4):L516-25.
Species: Human
Sample Types: Edema Fluid
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Higher plasma soluble Receptor for Advanced Glycation End Products (sRAGE) levels are associated with incident cardiovascular disease and all-cause mortality in type 1 diabetes: a 12-year follow-up study.
Authors: Nin JW, Jorsal A, Ferreira I
Diabetes, 2010-06-03;59(8):2027-32.
Species: Human
Sample Types: Plasma
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Circulating high-molecular-weight RAGE ligands activate pathways implicated in the development of diabetic nephropathy.
Authors: Penfold SA, Coughlan MT, Patel SK
Kidney Int., 2010-05-12;78(3):287-95.
Species: Human
Sample Types: Serum
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Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndrome.
Authors: Bastarache JA, Fremont RD, Kropski JA, Bossert FR, Ware LB
Am. J. Physiol. Lung Cell Mol. Physiol., 2009-08-21;297(6):L1035-41.
Species: Human
Sample Types: Edema Fluid
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Effects of atorvastatin on serum soluble receptors for advanced glycation end-products in type 2 diabetes.
Authors: Tam HL, Shiu SW, Wong Y, Chow WS, Betteridge DJ, Tan KC
Atherosclerosis, 2009-08-21;209(1):173-7.
Species: Human
Sample Types: Serum
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Characterization of RAGE, HMGB1, and S100beta in inflammation-induced preterm birth and fetal tissue injury.
Authors: Buhimschi CS, Baumbusch MA, Dulay AT, Oliver EA, Lee S, Zhao G, Bhandari V, Ehrenkranz RA, Weiner CP, Madri JA, Buhimschi IA
Am. J. Pathol., 2009-08-13;175(3):958-75.
Species: Human
Sample Types: Plasma
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Receptor for advanced glycation end products (RAGE) and its inflammatory ligand EN-RAGE in non-diabetic subjects with pre-mature coronary artery disease.
Authors: Mahajan N, Malik N, Bahl A
Atherosclerosis, 2009-06-11;207(2):597-602.
Species: Human
Sample Types: Plasma
-
Activation of critical, host-induced, metabolic and stress pathways marks neutrophil entry into cystic fibrosis lungs.
Authors: Makam M, Diaz D, Laval J, Gernez Y, Conrad CK, Dunn CE, Davies ZA, Moss RB, Herzenberg LA, Herzenberg LA, Tirouvanziam R
Proc. Natl. Acad. Sci. U.S.A., 2009-03-17;106(14):5779-83.
Species: Human
Sample Types: Plasma
-
Increased serum HMGB1 level is associated with coronary artery disease in nondiabetic and type 2 diabetic patients.
Authors: Yan XX, Lu L, Peng WH, Wang LJ, Zhang Q, Zhang RY, Chen QJ, Shen WF
Atherosclerosis, 2008-12-14;205(2):544-8.
Species: Human
Sample Types: Serum
-
Serum-soluble receptor for advanced glycation end product levels in patients with amyotrophic lateral sclerosis.
Acta Neurol. Scand., 2008-12-02;120(2):119-22.
Species: Human
Sample Types: Serum
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Nitric oxide inhalation and glucocorticoids as combined treatment in human experimental endotoxemia.
Authors: Hallstrom L, Berghall E, Frostell C, Sollevi A, Soop AL
Crit. Care Med., 2008-11-01;36(11):3043-7.
Species: Human
Sample Types: Plasma
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Serum endogenous secretory RAGE level is an independent risk factor for the progression of carotid atherosclerosis in type 1 diabetes.
Authors: Katakami N, Matsuhisa M, Kaneto H, Matsuoka TA, Sakamoto K, Yasuda T, Umayahara Y, Kosugi K, Yamasaki Y
Atherosclerosis, 2008-09-02;204(1):288-92.
Species: Human
Sample Types: Serum
-
Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury.
Authors: Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N, Matthay MA
Thorax, 2008-06-19;63(12):1083-9.
Species: Human
Sample Types: Plasma
-
MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis.
Authors: Rosas IO, Richards TJ, Konishi K, Zhang Y, Gibson K, Lokshin AE, Lindell KO, Cisneros J, Macdonald SD, Pardo A, Sciurba F, Dauber J, Selman M, Gochuico BR, Kaminski N
PLoS Med., 2008-04-29;5(4):e93.
Species: Human
Sample Types: Serum
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Low levels of sRAGE are associated with increased risk for mortality in renal transplant recipients.
Authors: Gross S, van Ree RM, Oterdoom LH, de Vries AP, van Son WJ, de Jong PE, Navis GJ, Zuurman MW, Bierhaus A, Gans RO, Bakker SJ
Transplantation, 2007-09-15;84(5):659-63.
Species: Human
Sample Types: Plasma
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