Human NFkB1 (NP_001158884.1) VersaClone cDNA

Human NFkB1 (NP_001158884.1) VersaClone cDNA Summary

Specifications

Product Datasheets

Background: NFkB1

NFkB1 (NFkB p50) and NFkB2 (NFkB p52) are class I members of the Rel/NFkB family of transcription factors that also includes RelA, c-Rel and RelB. Rel/NFkB members regulate expression of genes that participate in immune, apoptotic and oncogenic processes. Class I members lack a C-terminal transcriptional activation segment found in class II members, but contain an RHD (Rel homology domain) that mediates DNA binding, nuclear localization and dimerization. NFkB1 and NFkB2 105 and 100 kDa precursors are proteolytically cleaved to 50 and 52 kDa active subunits, respectively. NFkB is predominantly localized in the cytoplasm as a complex with inhibitory IkB proteins and is released and translocated to the nucleus after phosphorylation of IkB.

Related Research Areas

• Apoptosis Transcription Factors and Regulators
• Cancer Stem Cell Transcription Factors
• Chemokine Receptor Intracellular Signaling
• C-type Lectin Receptors
• Diabetic Peripheral Neuropathy
• EMT Induction
• IL-1 Family
• IL-17 Family
• Immunoglobulin-Like Domain Transcription Factors
• Interferons
• Intracellular Signaling Molecules in Angiogenesis
• Myeloid-derived Suppressor Cells (MDSC)
• Natural Killer T (NKT) Cells
• Neurotrophin/Trk Family
• NFkB Pathway
• NOD-like Receptors and the Inflammasome
• Notch Pathway
• PDGF Family
• Pluripotent Stem Cell Transcription Factors
• Positive Regulators of the Jak/STAT Pathway
• RIG-I-like Receptors
• TNF Superfamily Regulators
• Toll-Like Receptors
• Transcription Factors and Regulators
• Transcription Factors in the Akt Pathway
• Transcriptional Regulators in Allergy and Asthma