Human/Mouse CXCR7/RDC-1 PE-conjugated Antibody Summary
Accession # P25106
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of CXCR7/RDC‑1 in MCF‑7 Human Cell Line by Flow Cytometry. MCF-7 human breast cancer cell line was stained with Mouse Anti-Human/Mouse CXCR7/RDC-1 PE-conjugated Monoclonal Antibody (Catalog # FAB4227P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: CXCR7/RDC-1
The G protein-coupled receptor, RDC1, belongs to a subgroup of chemokine receptors and has been designated CXCR7. CXCR7 can bind with high-affinity to CXCL12/SDF-1 and CXCL11/I‑TAC. It is also a co-receptor for several HIV and SIV strains. In their N-termini and extracellular loops 1, 2, and 3, human and mouse CXCR7 share 84%, 100%, 96%, and 86% amino acid sequence identity, respectively. Reports of mRNA levels and/or protein expression (as assessed using anti-CXCR7, clone 9C4) (J. Biol. Chem. 2005, 280(42):35760, J. Immunol. 2006, 176(4):2197) indicate that CXCR7 occurs on a wide variety of tissues and cells including monocytes, B cells, T cells and mature dendritic cells. In contrast, based on ligand binding analysis and receptor level (as assessed using anti-CXCR7, clone 11G8), surface expression of CXCR7 was reported to be restricted to tumor cells, activated endothelial cells, fetal liver cells, and few other cell types (J. Exp. Med. 2006, 203(9):2201). The basis of these inconsistent observations is not known but may be attributed to cell context and the use of different antibodies that may recognize different epitopes.
Product Datasheets
Citations for Human/Mouse CXCR7/RDC-1 PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Frontline Science: CXCR7 mediates CD14(+)CD16(+) monocyte transmigration across the blood brain barrier: a potential therapeutic target for NeuroAIDS
Authors: M Veenstra, DW Williams, TM Calderon, K Anastos, S Morgello, JW Berman
J. Leukoc. Biol., 2017-07-28;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Migration, proliferation, and differentiation of cord blood mesenchymal stromal cells treated with histone deacetylase inhibitor valproic Acid.
Authors: Marquez-Curtis L, Qiu Y, Xu A, Janowska-Wieczorek A
Stem Cells Int, 2014-03-16;2014(0):610495.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity.
Authors: Simonetti, Giorgia, Carette, Amanda, Silva, Kathryn, Wang, Haowei, De Silva, Nilushi, Heise, Nicole, Siebel, Christia, Shlomchik, Mark J, Klein, Ulf
J Exp Med, 2013-12-09;210(13):2887-902.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
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