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Human MOG Antibody

Catalog #: AF2395
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
AF2395
AF2395-SP
MOG in Human Brain (Cerebellum).
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Citations (1)
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Human MOG Antibody Summary

Species Reactivity
Human
Specificity
Detects human MOG in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant human MOG
Gly30-Gly154 (Asp131Ala)
Accession # Q8IYG5
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Human MOG
Immunohistochemistry
5-15 µg/mL
Immersion fixed paraffin-embedded sections of human brain (cerebellum)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry View Larger

MOG in Human Brain (Cerebellum). MOG was detected in immersion fixed paraffin-embedded sections of human brain (cerebellum) using Goat Anti-Human MOG Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2395) at 10 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to neuronal processes. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: MOG

MOG is an Ig superfamily member found exclusively in myelinating oligodendrocytes in the central nervous system. Multiple isoforms of human MOG exist. The amino-terminal extracellular domain of human MOG shares 92% and 91% amino acid sequence homology with the corresponding regions of the mouse and rat protein, respectively.

Long Name
Myelin Oligodendrocyte Glycoprotein
Entrez Gene IDs
4340 (Human); 17441 (Mouse)
Alternate Names
MGC26137; MOG Ig-AluB; MOG; MOGIG2; myelin oligodendrocyte glycoprotein; myelin-oligodendrocyte glycoprotein

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Citation for Human MOG Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Oligodendroglial expression of TrkB independently regulates myelination and progenitor cell proliferation.
    Authors: Wong, Agnes W, Xiao, Junhua, Kemper, Dennis, Kilpatrick, Trevor J, Murray, Simon S
    J Neurosci, 2013-03-13;33(11):4947-57.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot

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