Human mGluR3 Biotinylated Antibody

Catalog #: BAF4668 Datasheet / COA / SDS

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BAF4668

All mGluR3 Antibodies

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Human mGluR3 Biotinylated Antibody Summary

Species Reactivity

Human

Specificity

Detects human mGluR3 in Western blots. In Western blots, less than 5% cross-reactivity with recombinant human (rh) mGluR2 is observed and less than 1% cross-reactivity with rhmGluR1, rhmGluR4, rhmGluR5, rhmGluR7, and rhmGluR8 is observed.

Source

Polyclonal Sheep IgG

Purification

Antigen Affinity-purified

Immunogen

Chinese hamster ovary cell line CHO-derived recombinant human mGluR3
Asp25-Ser507
Accession # Q14832

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Label

Biotin

Applications

Recommended Concentration

Sample

Western Blot

0.1 µg/mL

Recombinant Human mGluR3

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: mGluR3

Metabotropic glutamate receptor 3 (mGluR3) is a 90-100 kDa, 7-transmembrane glycoprotein that belongs to group II of the C-family of G-protein coupled receptors. It is a presynaptic receptor expressed on both neurons and glia, whose activation reduces adenylate cyclase activity. Mature human mGluR3 is 857 amino acids in length and contains a 554 amino acid (aa) N-terminal extracellular domain (ECD) (aa 23-576). The ECD binds glutamate and forms homodimers. There is one alternative splice form that is soluble, 515 aa in length and shows a 96 aa substitution for aa 442-879. Over aa 25-507, human mGluR3 shares 97% aa sequence identity with mouse and rat mGluR3 and 67% aa sequence identity with hGluR2.

Long Name

Metabotropic Glutamate Receptor 3

Entrez Gene IDs

2913 (Human); 108069 (Mouse); 24416 (Rat)

Alternate Names

GLUR3; glutamate receptor, metabotropic 3; GPRC1C; GPRC1Cglutamate metabotropic receptor 3; GRM3; mGlu3; mGluR3; MGLUR3metabotropic glutamate receptor 3