Human Lysyl Oxidase Homolog 2/LOXL2 Antibody Summary
Gln26-Gln744 (predicted)
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Lysyl Oxidase Homolog 2/LOXL2
Lysyl Oxidase Homolog 2 (lysyl oxidase-like protein 2, LOXL2) is a member of lysyl oxidase-like (LOXL) gene family which includes LOXL1 through LOXL4. These enzymes are secreted copper-binding amine oxidases that oxidize primary amine substrates to aldehydes (1). The N-terminal region of LOXL2 contains four scavenger receptor cysteine-rich (SRCR) domains, and the C-terminal region is a catalytic domain similar to other lysyl oxidases (1). The catalytic domain contains conserved residues required for copper binding and formation of a lysyl tyrosylquinone co-factor (2). Although some of the LOXL enzymes are known to cross-link collagen and elastin substrates, such a function has yet to be characterized for LOXL2. It has been shown that LOXL2 promotes cell migration and tumor cell invasiveness (3, 4). Elevated expression of LOXL2 is also associated with cancer progression in various tumors and carcinoma cell lines, which makes it a potential marker for prognosis of cancer (5). LOXL2 is expressed in many tissues, with elevated levels in reproductive tissues such as placenta, uterus, and prostate (6).
- Csiszar, H. (2001) Prog. Nucleic Acid Res. Mol. Biol. 70:1.
- Maki, J.M. and K.I. Kivirikko (2001) Biochem J. 355:381.
- Akiri, G. et al. (2003) Cancer Res. 63:1657.
- Hollosi, P. et al. (2009) Int. J. Cancer. 125:318.
- Peinado, H. et al. (2008) Cancer Res. 68:4541.
- Jourdan-Le Saux C. et al. (1999) J. Biol. Chem. 274:12939.
Product Datasheets
Citations for Human Lysyl Oxidase Homolog 2/LOXL2 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Gremlin utilizes canonical and non-canonical TGFbeta signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells.
Authors: Sethi A, Wordinger RJ, Clark AF.
Exp Eye Res.
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The interaction of LOXL2 with GATA6 induces VEGFA expression and angiogenesis in cholangiocarcinoma
Authors: Peng T, Deng X, Tian F et al.
Int. J. Oncol.
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Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction
Authors: S Vukicevic, A Colliva, V Kufner, V Martinelli, S Moimas, S Vodret, V Rumenovic, M Milosevic, B Brkljacic, D Delic-Brkl, R Correa, M Giacca, M Maglione, T Bordukalo-, I Dumic-Cule, S Zacchigna
Nature Communications, 2022-01-10;13(1):81.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway.
Authors: Peng L, Ran YL, Hu H, Yu L, Liu Q, Zhou Z, Sun YM, Sun LC, Pan J, Sun LX, Zhao P, Yang ZH
Carcinogenesis, 2009-07-22;30(10):1660-9.
Species: Human
Sample Types: Cell Lysates, Recombinant Protein
Applications: Immunoprecipitation, Western Blot
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