Human LIFR alpha (NP_002301) VersaClone cDNA

Human LIFR alpha (NP_002301) VersaClone cDNA Summary

Specifications

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Background: LIFR alpha

Based on its helical structure, LIF (Leukemia Inhibitory Factor) is considered a member of the Interleukin-6 family of cytokines. Functionally, it has been implicated in a many physiological processes including development, hematopoiesis, bone metabolism, and inflammation. Some cell types known to express LIF include activated T cells, monocytes, astrocytes, osteoblasts, keratinocytes, regenerating skeletal muscle, mast cells, and fibroblasts. The activities of LIF are mediated through a high-affinity heterodimeric receptor complex consisting of two membrane glycoproteins: an alpha subunit (LIF R alpha, also known as LIF R beta and CD118) that binds LIF with low affinity and the 130 kDa (gp130) subunit that does not bind LIF by itself, but is required for high-affinity binding of LIF by the complex.

Related Research Areas

• Cytokines and Receptors in Allergy and Asthma
• Diabetes
• Diabetes and Obesity Research
• IL-6 Family
• Megakaryocytes
• Obesity
• Receptors in the Jak/STAT Pathway
• Reproduction