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Human KA1/GRIK4 Antibody

Catalog #: MAB11326 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB11326-100
MAB11326-SP
Detection of KA1/GRIK4 in Human Hippocampus.
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Human KA1/GRIK4 Antibody Summary

Species Reactivity
Human
Specificity
Detects human KA1/GRIK in direct ELISA.
Source
Monoclonal Mouse IgG2B Clone # 1060003
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Human KA1/GRIK containing peptide
Accession # P42263
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Immunohistochemistry
5-25 µg/mL
Immersion fixed paraffin-embedded sections of Human Hippocampus

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry View Larger

Detection of KA1/GRIK4 in Human Hippocampus. KA1/GRIK4 was detected in immersion fixed paraffin-embedded sections of Human Hippocampus using Mouse Anti-Human KA1/GRIK4 Monoclonal Antibody (Catalog # MAB11326) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC001). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using VisUCyte Antigen Retrieval Reagent-Basic (Catalog # VCTS021). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in neuronal cells. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: KA1/GRIK4

GRIK4 (Glutamate receptor, ionotropic kainate 4) is a receptor for glutamate and is one of the 5 types of kainate receptor subunits.  Glutamate acts as an excitatory neurotransmitter at many synapses in the CNS are key mediators of brain communication.  Kainate receptors are relevant targets for neuroprotection of both neurons and glia in acute and chronic neurodegerative diseases.  They are also involved in epilepsy, pain and psychiatric disorders.  Variations in GRIK4 have been associated with both increased and decreased risk of bipolar disorder.  Single-nucleotide polymorphism's in GRIK 4 are also observed in Schizophrenia.

References
  1. Entrez Gene: GRIK4 glutamate receptor, ionotropic, kainate 4.
  2. Szpirer C, Molne M, Antonacci R, Jenkins NA, Finelli P, Szpirer J, Riviere M, Gilbert DJ, Copeland NG, et al.  "The Genes Encoding the Glutamate Receptor Subunits Ka1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in Human, Mouse and Rat". Proc Natl Acad Sci U.S.A. 1995 Jan; 91(25):11849-53.
  3. Contractor A, Mulle C, Swanson GT. "Kainate Receptors Coming of Age: Milestones of Two Decades of Research". Trends in Neurosciences. 2011 Mar; 34(3):154.
  4. Matute C. "Therapeutic Potential of Kainate Receptors". CNS Neuroscience & Therapeutics. 2011 Dec; 17(6):661.   
Long Name
Glutamate Receptor KA1
Entrez Gene IDs
2900 (Human); 110637 (Mouse); 24406 (Rat)
Alternate Names
EAA1; Excitatory amino acid receptor 1; GluK4; glutamate receptor KA1; Glutamate receptor KA-1; glutamate receptor, ionotropic kainate 4; glutamate receptor, ionotropic, kainate 4; GRIK4; KA1; KA1GRIK

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