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Human IL-18/IL-1F4 ELISA

Catalog #: 7620
43 Citations Datasheet / COA / SDS
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Human IL-18/IL-1F4 Quantikine ELISA Kit is now available!
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7620
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Citations (43)
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Human IL-18/IL-1F4 ELISA Summary

Sample Type & Volume Required Per Well
Cell Culture Supernates (150 uL), Serum (30 uL), EDTA Plasma (30 uL), Urine (150 uL)
Sensitivity
12.5 pg/mL
Assay Range
25.6 - 1,000 pg/mL
Cross-reactivity
< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
Interference
No significant interference observed with available related molecules.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: IL-18/IL-1F4

Interleukin 18 (IL-18), also known as interferon-gamma-inducing factor (IGIF) and IL-1γ, is a cytokine which shares biologic activities with IL-12 and structural similarities with the IL-1 family of proteins. IL-18 was originally cloned from liver cells and has since been shown to be expressed by monocyte/macrophages, osteoblasts and keratinocytes. Caspase-1 (IL-1 beta-converting enzyme) has been implicated in the physiological processing of pro-IL-18 to IL-18. Similarly to IL-12, human IL-18 has been shown to enhance NK cell activity in PBMC cultures. Human IL-18 has also been found to induce the production IFN-γ and GM-CSF while inhibiting the production of IL-10 by PBMC. On enriched human T cells, human IL-18 can enhance Th1 cytokine production and stimulate cell proliferation via an IL-2-dependent pathway. In the mouse system, IL-18 has been shown to be a costimulatory factor for the activation of Th1, but not Th2, cells. IL-18 was found to selectively enhance the FasL-mediated cytotoxicity of Th1, but not Th0 or Th2, cells. IL-18 has also been shown to induce activated B cells to produce IFN-γ that inhibits IgE production.

Long Name:
Interleukin 18
Entrez Gene IDs:
3606 (Human); 16173 (Mouse); 29197 (Rat); 397057 (Porcine); 574151 (Primate)
Alternate Names:
Iboctadekin; IFN-gamma-inducing factor; IGIF; IGIFIL-1 gamma; IL18; IL-18; IL-18MGC12320; IL-1F4; IL1F4iboctadekin; IL-1g; Interferon gamma-inducing factor; interleukin 18 (interferon-gamma-inducing factor); Interleukin-1 gamma; interleukin-18

Citations for Human IL-18/IL-1F4 ELISA

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

43 Citations: Showing 1 - 10
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  1. Extreme altitude induces divergent mass reduction of right and left ventricle in mountain climbers
    Authors: C Udjus, I Sjaastad, U Hjørnholm, TK Tunestveit, P Hoffmann, A Hinojosa, EKS Espe, G Christense, OH Skjønsberg, KO Larsen, M Rostrup
    Physiological Reports, 2022-02-01;10(3):e15184.
    Species: Human
    Sample Types: Serum
  2. The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1&beta and IL-18 secretion
    Authors: S Sukhanov, Y Higashi, T Yoshida, S Mummidi, AR Aroor, J Jeffrey Ru, SB Bender, VG DeMarco, B Chandrasek
    Cell Signal, 2020-11-04;77(0):109825.
    Species: Human
    Sample Types: Cell Culture Supernates
  3. Effects of Kudiezi Injection on Serum Inflammatory Biomarkers in Patients with Acute Cerebral Infarction
    Authors: X Liu, X Jin, B Chen, X Liu, X Liang, X Fang, H Wu, X Fu, H Zheng, X Ding, N Duan, Y Zhang
    Dis. Markers, 2018-09-02;2018(0):7936736.
    Species: Human
    Sample Types: Serum
  4. Epstein-Barr virus infection-induced inflammasome activation in human monocytes
    Authors: Y Torii, JI Kawada, T Murata, H Yoshiyama, H Kimura, Y Ito
    PLoS ONE, 2017-04-03;12(4):e0175053.
    Species: Human
    Sample Types: Cell Culture Supernates
  5. Potential protein biomarkers for burning mouth syndrome discovered by quantitative proteomics
    Authors: EH Ji, C Diep, T Liu, H Li, R Merrill, D Messadi, S Hu
    Mol Pain, 2017-01-01;13(0):1744806916686.
    Species: Human
    Sample Types: Saliva
  6. Serum Interleukin-18, Fetuin-A, Soluble Intercellular Adhesion Molecule-1, and Endothelin-1 in Ankylosing Spondylitis, Psoriatic Arthritis, and SAPHO Syndrome
    Int J Mol Sci, 2016-08-03;17(8):.
    Species: Human
    Sample Types: Serum
  7. Rickettsia australis Activates Inflammasome in Human and Murine Macrophages
    PLoS ONE, 2016-06-30;11(6):e0157231.
    Species: Human
    Sample Types: Cell Culture Supernates
  8. Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2 E3 Ligase.
    Authors: Han S, Lear T, Jerome J, Rajbhandari S, Snavely C, Gulick D, Gibson K, Zou C, Chen B, Mallampalli R
    J Biol Chem, 2015-06-02;290(29):18124-33.
    Species: Human
    Sample Types: Cell Culture Supernates
  9. Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver.
    Authors: Jo J, Tan A, Ussher J, Sandalova E, Tang X, Tan-Garcia A, To N, Hong M, Chia A, Gill U, Kennedy P, Tan K, Lee K, De Libero G, Gehring A, Willberg C, Klenerman P, Bertoletti A
    PLoS Pathog, 2014-06-26;10(6):e1004210.
    Species: Human
    Sample Types: Cell Culture Supernates
  10. Randomized comparison of single dose of recombinant human IL-12 versus placebo for restoration of hematopoiesis and improved survival in rhesus monkeys exposed to lethal radiation.
    Authors: Gluzman-Poltorak Z, Mendonca S, Vainstein V, Kha H, Basile L
    J Hematol Oncol, 2014-04-06;7(0):31.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Plasma
  11. Exosomes from red blood cell units bind to monocytes and induce proinflammatory cytokines, boosting T-cell responses in vitro.
    Authors: Danesh A, Inglis H, Jackman R, Wu S, Deng X, Muench M, Heitman J, Norris P
    Blood, 2013-12-12;123(5):687-96.
    Species: Human
    Sample Types: Cell Culture Supernates
  12. A bone substitute with high affinity for vitamin D-binding protein--relationship with niche of osteoclasts.
    Authors: Ikeda T, Kasai M, Tatsukawa E, Kamitakahara M, Shibata Y, Yokoi T, Nemoto T, Ioku K
    J Cell Mol Med, 2013-11-28;18(1):170-80.
    Species: Human
    Sample Types: BALF
  13. Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults.
    Authors: Matteini A, Li J, Lange E, Tanaka T, Lange L, Tracy R, Wang Y, Biggs M, Arking D, Fallin M, Chakravarti A, Psaty B, Bandinelli S, Ferrucci L, Reiner A, Walston J
    Cytokine, 2013-10-29;65(1):10-6.
    Species: Human
    Sample Types: Serum
  14. Regulation of viral and cellular gene expression by Kaposi's sarcoma-associated herpes virus polyadenylated nuclear RNA.
    Authors: Rossetto, Cyprian, Tarrant-Elorza, Margaret, Verma, Subhash, Purushothaman, Pravinku, Pari, Gregory
    J Virol, 2013-03-06;87(10):5540-53.
    Species: Human
    Sample Types: Whole Cells
  15. Quiescent innate response to infective filariae by human Langerhans cells suggests a strategy of immune evasion.
    Authors: Boyd A, Bennuru S, Wang Y, Sanprasert V, Law M, Chaussabel D, Nutman T, Semnani R
    Infect Immun, 2013-02-19;81(5):1420-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  16. Compensated inflammation in systemic juvenile idiopathic arthritis: role of alternatively activated macrophages.
    Authors: Shimizu M, Yachie A
    Cytokine, 2012-06-08;60(1):226-32.
    Species: Human
    Sample Types: Serum
  17. Acute kidney injury biomarkers for patients in a coronary care unit: a prospective cohort study.
    Authors: Chen TH, Chang CH, Lin CY, Jenq CC, Chang MY, Tian YC, Hung CC, Fang JT, Yang CW, Wen MS, Lin FC, Chen YC
    PLoS ONE, 2012-02-22;7(2):e32328.
    Species: Human
    Sample Types: Serum
  18. Differentiation of human SH-SY5Y neuroblastoma cells by all-trans retinoic acid activates the interleukin-18 system.
    Authors: Sallmon H, Hoene V, Weber SC, Dame C
    J. Interferon Cytokine Res., 2010-02-01;30(2):55-8.
    Species: Human
    Sample Types: Cell Culture Supernates
  19. IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis.
    Authors: Reeves EP, Williamson M, Byrne B, Bergin DA, Smith SG, Greally P, O'Kennedy R, O'Neill SJ, McElvaney NG
    J. Immunol., 2009-12-21;184(3):1642-52.
    Species: Human
    Sample Types: Serum
  20. AIDS progression is associated with the emergence of IL-17-producing cells early after simian immunodeficiency virus infection.
    Authors: Campillo-Gimenez L, Cumont MC, Fay M, Kared H, Monceaux V, Diop O, Muller-Trutwin M, Hurtrel B, Levy Y, Zaunders J, Dy M, Leite-de-Moraes MC, Elbim C, Estaquier J
    J. Immunol., 2009-12-16;184(2):984-92.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Plasma
  21. Changes in cytokine levels during acute hyperinsulinemia in offspring of type 2 diabetic subjects.
    Authors: Ruotsalainen E, Stancakova A, Vauhkonen I, Salmenniemi U, Pihlajamaki J, Punnonen K, Laakso M
    Atherosclerosis, 2009-12-02;210(2):536-41.
    Species: Human
    Sample Types: Plasma
  22. The imbalance in serum concentration of Th-1- and Th-2-derived chemokines as one of the factors involved in pathogenesis of atopic dermatitis.
    Authors: Narbutt J, Lesiak A, Sysa-Jedrzeiowska A, Zakrzewski M, Bogaczewicz J, Stelmach I, Kuna P
    Mediators Inflamm., 2009-07-22;2009(0):269541.
    Species: Human
    Sample Types: Serum
  23. Associations of circulating TNFalpha and IL-18 with myocardial infarction and cardiovascular risk markers: the Glasgow Myocardial Infarction Study.
    Authors: Welsh P, Woodward M, Rumley A, Lowe G
    Cytokine, 2009-07-05;47(2):143-7.
    Species: Human
    Sample Types: Plasma
  24. Resveratrol blocks interleukin-18-EMMPRIN cross-regulation and smooth muscle cell migration.
    Authors: Venkatesan B, Valente AJ, Reddy VS, Siwik DA, Chandrasekar B
    Am. J. Physiol. Heart Circ. Physiol., 2009-06-26;297(2):H874-86.
    Species: Human
    Sample Types: Cell Culture Supernates
  25. Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome.
    Authors: Duncan JA, Gao X, Huang MT, O'Connor BP, Thomas CE, Willingham SB, Bergstralh DT, Jarvis GA, Sparling PF, Ting JP
    J. Immunol., 2009-05-15;182(10):6460-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  26. Interleukin-18 predicts atherosclerosis progression in SIV-infected and uninfected rhesus monkeys (Macaca mulatta) on a high-fat/high-cholesterol diet.
    Authors: Yearley JH, Xia D, Pearson CB, Carville A, Shannon RP, Mansfield KG
    Lab. Invest., 2009-04-20;89(6):657-67.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Plasma
  27. Contribution of novel biomarkers to incident stable angina and acute coronary syndrome: the PRIME Study.
    Authors: Empana JP, Canoui-Poitrine F, Luc G, Juhan-Vague I, Morange P, Arveiler D, Ferrieres J, Amouyel P, Bingham A, Montaye M, Ruidavets JB, Haas B, Evans A, Ducimetiere P
    Eur. Heart J., 2008-07-10;29(16):1966-74.
    Species: Human
    Sample Types: Plasma
  28. Gender specific associations between matrix metalloproteinases and inflammatory markers in post myocardial infarction patients.
    Authors: Samnegard A, Hulthe J, Silveira A, Ericsson CG, Hamsten A, Eriksson P
    Atherosclerosis, 2008-06-05;202(2):550-6.
    Species: Human
    Sample Types: Plasma
  29. Interleukin-18 and the risk of future cardiovascular disease among initially healthy women.
    Authors: Everett BM, Bansal S, Rifai N, Buring JE, Ridker PM
    Atherosclerosis, 2008-04-22;202(1):282-8.
    Species: Human
    Sample Types: Plasma
  30. Antigenic stimulation in the simian model of HIV infection yields dilated cardiomyopathy through effects of TNFalpha.
    Authors: Yearley JH, Mansfield KG, Carville AA, Sokos GG, Xia D, Pearson CB, Shannon RP
    AIDS, 2008-03-12;22(5):585-94.
    Species: Human
    Sample Types: Plasma
  31. IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation.
    Authors: Kang MJ, Homer RJ, Gallo A, Lee CG, Crothers KA, Cho SJ, Rochester C, Cain H, Chupp G, Yoon HJ, Elias JA
    J. Immunol., 2007-02-01;178(3):1948-59.
    Species: Human
    Sample Types: Serum
  32. Haplotypes of the caspase-1 gene, plasma caspase-1 levels, and cardiovascular risk.
    Authors: Blankenberg S, Godefroy T, Poirier O, Rupprecht HJ, Barbaux S, Bickel C, Nicaud V, Schnabel R, Kee F, Morrison C, Evans A, Lackner KJ, Cambien F, Munzel T, Tiret L
    Circ. Res., 2006-06-15;99(1):102-8.
    Species: Human
    Sample Types: Plasma
  33. Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma.
    Authors: Yamanaka K, Clark R, Dowgiert R, Hurwitz D, Shibata M, Rich BE, Hirahara K, Jones DA, Eapen S, Mizutani H, Kupper TS
    Clin. Cancer Res., 2006-01-15;12(2):376-82.
    Species: Human
    Sample Types: Plasma
  34. The proatherogenic cytokine interleukin-18 is secreted by human adipocytes.
    Authors: Skurk T, Kolb H, Muller-Scholze S, Rohrig K, Hauner H, Herder C
    Eur. J. Endocrinol., 2005-06-01;152(6):863-8.
    Species: Human
    Sample Types: Cell Culture Supernates
  35. Soluble interleukin-1 receptor type II, IL-18 and caspase-1 in mild cognitive impairment and severe Alzheimer's disease.
    Authors: Lindberg C, Chromek M, Ahrengart L, Brauner A, Schultzberg M, Garlind A
    Neurochem. Int., 2005-06-01;46(7):551-7.
    Species: Human
    Sample Types: Serum
  36. The effect of the physical characteristics of hydroxyapatite particles on human monocytes IL-18 production in vitro.
    Authors: Grandjean-Laquerriere A, Laquerriere P, Laurent-Maquin D, Guenounou M, Phillips TM
    Biomaterials, 2004-12-01;25(28):5921-7.
    Species: Human
    Sample Types: Cell Culture Supernates
  37. Interleukin-18 levels correlate with severe ovarian hyperstimulation syndrome.
    Authors: Barak V, Elchalal U, Edelstein M, Kalickman I, Lewin A, Abramov Y
    Fertil. Steril., 2004-08-01;82(2):415-20.
    Species: Human
    Sample Types: Plasma
  38. Production of interferon gamma in respiratory syncytial virus infection of humans is not associated with interleukins 12 and 18.
    Authors: Garofalo RP, Hintz KH, Hill V, Ogra PL, Welliver RC
    J. Med. Virol., 2004-06-01;73(2):289-94.
    Species: Human
    Sample Types: Tissue Secretion
  39. Reduced levels of transforming growth factor-beta1, interleukin-12 and increased migration inhibitory factor are associated with severe malaria.
    Authors: Chaiyaroj SC, Rutta AS, Muenthaisong K, Watkins P, Na Ubol M, Looareesuwan S
    Acta Trop., 2004-02-01;89(3):319-27.
    Species: Human
    Sample Types: Plasma
  40. NK cells regulate CD8+ T cell effector function in response to an intracellular pathogen.
    Authors: Vankayalapati R, Klucar P, Wizel B, Weis SE, Samten B, Safi H, Shams H, Barnes PF
    J. Immunol., 2004-01-01;172(1):130-7.
    Species: Human
    Sample Types: Cell Culture Supernates
  41. Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection.
    Authors: Geisbert TW, Hensley LE, Larsen T, Young HA, Reed DS, Geisbert JB, Scott DP, Kagan E, Jahrling PB, Davis KJ
    Am. J. Pathol., 2003-12-01;163(6):2347-70.
    Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
    Sample Types: Serum
  42. Local immunostimulation induced by intravesical administration of autologous interferon-gamma-activated macrophages in patients with superficial bladder cancer.
    Authors: Pages F, Lebel-Binay S, Vieillefond A, Deneux L, Cambillau M, Soubrane O, Debre B, Tardy D, Lemonne JL, Abastado JP, Fridman WH, Thiounn N
    Clin. Exp. Immunol., 2002-02-01;127(2):303-9.
    Species: Human
    Sample Types: Urine
  43. Cytokine profile in Behcet's disease patients. Relationship with disease activity.
    Authors: Hamzaoui K, Hamzaoui A, Guemira F, Bessioud M, Hamza M, Ayed K
    Scand. J. Rheumatol., 2002-01-01;31(4):205-10.
    Species: Human
    Sample Types: Serum

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