Human IFN-alpha Multi-Subtype ELISA Kit

Name: Human IFN-alpha Multi-Subtype ELISA Kit
Brand: R&D Systems
SKU: 41105-1
Price: 755 USD

Catalog #: 41105-1
4 Citations Datasheet / COA / SDS

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Product Details

Citations (4)

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Summary Product Datasheets Preparation and Storage Background Related Research Areas

Human IFN-alpha Multi-Subtype ELISA Kit Summary

Assay Length

3.25 hours

Sample Type & Volume Required Per Well

Cell Culture Supernates (100 uL)

Sensitivity

12.5 pg/mL

Assay Range

156.0 - 5,000 pg/mL (Cell Culture Supernates)12.5 - 500 pg/mL (Cell Culture Supernates),

Specificity

Human IFN-alpha

Cross-reactivity

< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.

Interference

No significant interference observed with available related molecules.

Product Summary

Product Datasheets

Product Datasheet

COA

SDS

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: IFN-alpha

Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.

Long Name:

Interferon alpha

Entrez Gene IDs:

3440 (Human)

Alternate Names:

IFNA; IFNA2; IFNA2b; IFNalpha; IFN-alpha; IFN-alphaA; INFA2; interferon alpha 2; LeIF D

Related Research Areas

Citations for Human IFN-alpha Multi-Subtype ELISA Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

4 Citations: Showing 1 - 4
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Hepatitis C virus pathogen associated molecular pattern (PAMP) triggers production of lambda-interferons by human plasmacytoid dendritic cells.
Authors: Stone, Amy E L, Giugliano, Silvia, Schnell, Gretja, Cheng, Linling, Leahy, Katelyn, Golden-Mason, Lucy, Gale, Michael, Rosen, Hugo R
PLoS Pathog, 2013-04-18;9(4):e1003316.
Species: Human
Sample Types: Cell Culture Supernates
Interleukin-27 is a potent inhibitor of cis HIV-1 replication in monocyte-derived dendritic cells via a type I interferon-independent pathway.
Authors: Chen, Qian, Swaminathan, Sanjay, Yang, De, Dai, Lue, Sui, Hongyan, Yang, Jun, Hornung, Ronald L, Wang, Yanmei, Huang, Da Wei, Hu, Xiaojun, Lempicki, Richard, Imamichi, Tomozumi
PLoS ONE, 2013-03-20;8(3):e59194.
Species: Human
Sample Types: Cell Culture Supernates
Protection from RNA and DNA viruses by IL-32.
Authors: Zepp JA, Nold-Petry CA, Dinarello CA, Nold MF
J. Immunol., 2011-02-23;186(7):4110-8.
Species: Human
Sample Types: Cell Culture Supernates
Endogenous IL-32 controls cytokine and HIV-1 production.
Authors: Nold MF, Nold-Petry CA, Pott GB, Zepp JA, Saavedra MT, Kim SH, Dinarello CA
J. Immunol., 2008-07-01;181(1):557-65.
Species: Human
Sample Types: Cell Culture Supernates