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Human IFN-alpha / beta  R1 PE-conjugated Antibody

Catalog #: FAB245P
7 Citations Datasheet / COA / SDS
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FAB245P
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Detection of IFN‑ alpha / beta R1 in U937 Human cell line by Flow Cytometry.
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Citations (7)
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human IFN-alpha / beta  R1 PE-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human IFN-alpha / beta R1 in direct ELISAs and Western blots. In direct ELISAs, does not cross-react with recombinant human (rh) IFN‑ gamma  R1, rhIFN-gamma R2, recombinant mouse IFN-alpha / beta  R2, rhIL-10 R beta, rhIL-10 R alpha, or rhIL-20 R beta.
Source
Monoclonal Mouse IgG1 Clone # 85228
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IFN-alpha / beta  R1
Lys28-Lys436
Accession # AAA52730
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of IFN-a/ beta R1 antibody in U937 Human cell line antibody by Flow Cytometry. View Larger

Detection of IFN‑ alpha / beta R1 in U937 Human cell line by Flow Cytometry. U937 human histiocytic lymphoma cell line was stained with Mouse Anti-Human IFN-a/ beta R1 PE-conjugated Monoclonal Antibody (Catalog # FAB245P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: IFN-alpha/beta R1

Type I interferons (IFN-alpha, IFN-beta, IFN-omega ) bind to the type I IFN receptor, also called the IFN alpha/beta receptor. This receptor is composed of two chains, IFN-alpha / beta R1 and R2.

Long Name
Interferon alpha/beta Receptor 1
Entrez Gene IDs
3454 (Human); 15975 (Mouse); 101926190 (Cynomolgus Monkey)
Alternate Names
alpha-type antiviral protein; AVP; beta-type antiviral protein; CRF2-1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC; IFN-alpha/beta R1; IFN-alpha/beta receptor 1; IFN-alpha-REC; IFNAR; IFNAR1; IFN-aR1; IFNBR; IFNbR1; IFN-bR1; IFN-R-1; interferon (alpha, beta and omega) receptor 1; interferon alpha/beta receptor 1; interferon-alpha/beta receptor alpha chain; interferon-beta receptor 1; Type I interferon receptor 1

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Product Specific Notices

Sold under license from Pestka Biomedical Laboratories, Inc. d/b/a PBL Interferon Source.

Citations for Human IFN-alpha / beta  R1 PE-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

7 Citations: Showing 1 - 7
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  1. AXL Expression on Homeostatic Resident Liver Macrophages Is Reduced in Cirrhosis Following GAS6 Production by Hepatic Stellate Cells
    Authors: Oltin-Tiberiu Pop, Anne Geng, Emilio Flint, Arjuna Singanayagam, Caner Ercan, Lucia Possamai et al.
    Cellular and Molecular Gastroenterology and Hepatology
  2. Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis
    Authors: Sampath Katakam, Santosh Anand, Patricia Martin, Nicolo Riggi, Ivan Stamenkovic
    Life Science Alliance
  3. Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism
    Authors: S Gupta, S Nakabo, LP Blanco, LJ O'Neil, G Wigerblad, RR Goel, P Mistry, K Jiang, C Carmona-Ri, DW Chan, X Wang, HL Pedersen, M Gadkari, KN Howe, F Naz, S Dell'Orso, SA Hasni, C Dempsey, A Buscetta, PA Frischmeye, P Kruszka, M Muenke, LM Franco, HW Sun, MJ Kaplan
    Proc. Natl. Acad. Sci. U.S.A., 2020-06-29;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  4. Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling
    Authors: PJ Metz, KA Ching, T Xie, P Delgado Cu, S Niessen, JH Tatlock, K Jensen-Per, BW Murray
    Cell Rep, 2020-02-11;30(6):1935-1950.e8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  5. Safe and effective treatment of experimental neuroblastoma and glioblastoma using systemically administered triple microRNA-detargeted oncolytic Semliki Forest virus
    Clin Cancer Res, 2016-09-16;0(0):.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  6. Type I interferon (IFN-alpha/beta) rescues B-lymphocytes from apoptosis via PI3Kdelta/Akt, Rho-A, NFkappaB and Bcl-2/Bcl(XL).
    Authors: Badr G, Saad H, Waly H
    Cell. Immunol., 2010-02-24;263(1):31-40.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  7. Enhancement of cell type specificity by quantitative modulation of a chimeric ligand.
    Authors: Cironi P, Swinburne IA, Silver PA
    J. Biol. Chem., 2008-01-29;283(13):8469-76.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry

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