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Human HLA-DR Antibody

Catalog #: MAB4869
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB4869
MAB4869-SP
Product Details
Citations (4)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human HLA-DR Antibody Summary

Species Reactivity
Human
Specificity
Detects human HLA‑DR.
Source
Monoclonal Mouse IgG1 Clone # L203
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
RPMI 8866 human lymphoblastoid cells
Accession # P01903
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Flow Cytometry
2.5 µg/106 cells
Human peripheral blood lymphocytes
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: HLA-DR

HLA-DR is a transmembrane human major histocompatibility complex 2 (MHC II) family member and consists of a 34 kDa (alpha) subunit and one of several 28 kDa (beta) subunits. HLA-DR is expressed primarily by B cells and dendritic cells (DC), in which it binds peptides derived from internalized and processed antigenic proteins. It presents these peptides on the cell surface for recognition by the T cell receptor on CD4+ T cells. This interaction is central to antigen specificity in the adaptive immune response. HLA-DR alleles, polymorphisms, and aberrant expression are linked to a variety of diseases including autoimmunity and cancer.

Long Name
Major Histocompatibility Complex Class II DR
Entrez Gene IDs
3122 (Human)
Alternate Names
FLJ51114; histocompatibility antigen HLA-DR alpha; HLA class II histocompatibility antigen, DR alpha chain; HLADR; HLA-DR; HLA-DRA; HLA-DRA1; major histocompatibility complex, class II, DR alpha; MHC cell surface glycoprotein; MHC class II antigen DRA; MHC Class II DR; MLRW

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Citations for Human HLA-DR Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

4 Citations: Showing 1 - 4
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  1. Comparison of the biological characteristics of human mesenchymal stem cells derived from exfoliated deciduous teeth, bone marrow, gingival tissue, and umbilical cord
    Authors: J Li, SQ Xu, YM Zhao, S Yu, LH Ge, BH Xu
    Mol Med Rep, 2018-09-20;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  2. Characterization and application of two RANK-specific antibodies with different biological activities.
    Authors: Chypre M, Seaman J, Cordeiro O, Willen L, Knoop K, Buchanan A, Sainson R, Williams I, Yagita H, Schneider P, Mueller C
    Immunol Lett, 2016-01-07;171(0):5-14.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  3. Involvement of the TNF-alpha/TGF-beta/IDO axis in IVIg-induced immune tolerance.
    Authors: Loubaki L, Chabot D, Bazin R
    Cytokine, 2014-11-19;71(2):181-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  4. IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response.
    Authors: Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A
    J. Allergy Clin. Immunol., 2008-12-03;123(1):59-66.e4.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization

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