Human Histamine H1 R Antibody Summary
Met1-Ser487
Accession # AAH60802
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
![Detection of Histamine H1 R antibody in PMA-treated U937 Human Cell Line antibody by Flow Cytometry. Detection of Histamine H1 R antibody in PMA-treated U937 Human Cell Line antibody by Flow Cytometry.](https://resources.rndsystems.com/images/datasheets/antibody/Histamine_H1_R_MAB4726_Flow_Cytometry_2664.jpg)
Detection of Histamine H1 R in PMA‑treated U937 Human Cell Line by Flow Cytometry. U937 human histiocytic lymphoma cell line treated with 50 ng/mL PMA for 24 hours was stained with Mouse Anti-Human Histamine H1 R Monoclonal Antibody (Catalog # MAB4726, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), followed by Allophycocyanin-conjugated Anti-Mouse IgG F(ab')2Secondary Antibody (Catalog # F0101B).
![Detection of Histamine H1 R antibody in U937 Human Cell Line antibody by Flow Cytometry. Detection of Histamine H1 R antibody in U937 Human Cell Line antibody by Flow Cytometry.](https://resources.rndsystems.com/images/datasheets/antibody/Histamine_H1_R_MAB4726_Flow_Cytometry_12631.jpg)
Detection of Histamine H1 R in U937 Human Cell Line by Flow Cytometry. U937 human histiocytic lymphoma cell line was stained with Mouse Anti-Human Histamine H1 R Monoclonal Antibody (Catalog # MAB4726, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), followed by Allophycocyanin-conjugated Anti-Mouse IgG F(ab')2Secondary Antibody (Catalog # F0101B).
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Histamine H1 R
Histamine H1 R (HRH1) is a 60 kDa, 487 aa G-protein coupled 7-transmembrane putative glycoprotein. It is implicated in the pathogenesis of asthma and is a major pharmaceutical target for antihistamines. It has been detected as a mixture of monomers and homodimers, with highest concentration in the placenta, followed by brain, lung (produced by airway smooth muscle, bronchial epithelium and macrophages) and other tissues. Extracellular domains of human HRH1 share 72% aa sequence identity with corresponding regions of mouse or rat HRH1.
Product Datasheets
Citations for Human Histamine H1 R Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Evidence of promiscuous endothelial binding by P lasmodium falciparum ‐infected erythrocytes
Authors: Claudia Esser, Anna Bachmann, Daniela Kuhn, Kathrin Schuldt, Birgit Förster, Meike Thiel et al.
Cellular Microbiology
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Mycobacterium tuberculosis Utilizes Host Histamine Receptor H1 to Modulate Reactive Oxygen Species Production and Phagosome Maturation via the p38MAPK-NOX2 Axis
Authors: S Mo, J Guo, T Ye, X Zhang, J Zeng, Y Xu, B Peng, Y Dai, W Xiao, P Zhang, G Deng, D Xu, X Long, Y Cai, X Chen
MBio, 2022-08-24;0(0):e0200422.
Species: Human
Sample Types: Cell Lysates
Applications: Flow Cytometry
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