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Human FGF-10 Antibody

Catalog #: MAB345
8 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB345
MAB345-SP
Product Details
Citations (8)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human FGF-10 Antibody Summary

Species Reactivity
Human
Specificity
Detects human FGF-10 in Western blots. Does not cross-react with recombinant human FGF-3, -5, -6, -7, -9, -13, or -19.
Source
Monoclonal Mouse IgG2B Clone # 186803
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
E. coli-derived recombinant human FGF-10
Cys37-Ser208
Accession # O15520
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human FGF‑10 (Catalog # 345-FG)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: FGF-10

The FGFs are a growing family of heparin-binding growth factors that show a variety of biological activities toward cells of mesenchymal, neuronal and epithelial origin. All FGFs have two conserved cysteine residues and share significant amino acid sequence homology. FGF-10 was originally identified from rat embryos by homology-based polymerase chain reaction. Human and mouse FGF-10 were subsequently cloned. The human FGF-10 cDNA encodes a 208 amino acid residue protein with a hydrophobic amino-terminal signal peptide. Human FGF-10 shares approximately 92% and 95% amino acid sequence identity with mouse and rat FGF‑10, respectively. Among the FGF family members, FGF-10 is most closely related to FGF-7. The expression of FGF-10 transcripts has been shown to be most abundant in the embryo and adult lung. Recombinant FGF-10 preparations have been shown to be mitogenic for epithelial and epidermal cells but not fibroblasts. Based on its in vitro biological activities and in vivo expression pattern, FGF-10 has been proposed to play unique roles in the brain, in lung development, wound healing and limb bud formation.

References
  1. Yamasaki, M. et al. (1996) J. Biol. Chem. 271:15918.
  2. Emoto, H. et al. (1997) J. Biol. Chem. 272:23191.
  3. Ohuchi, H. et al. (1997) Development 124:2235.
  4. Tagashira, S. et al. (1997) Gene 197:399.
  5. Bellusci, S. et al. (1997) Development 124:4867.
Long Name
Fibroblast Growth Factor 10
Entrez Gene IDs
2255 (Human); 14165 (Mouse); 25443 (Rat)
Alternate Names
FGF10; FGF-10; fibroblast growth factor 10; Keratinocyte growth factor 2; KGF2; KGF-2; produced by fibroblasts of urinary bladder lamina propria

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Citations for Human FGF-10 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

8 Citations: Showing 1 - 8
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  1. Sex differences in glucoprivic regulation of glycogen metabolism in hypothalamic primary astrocyte cultures: Role of estrogen receptor signaling
    Authors: Ibrahim MMH, Bheemanapally K, Sylvester PW, Briski KP
    Mol. Cell. Endocrinol.
  2. Transplantable human motor networks as a neuron-directed strategy for spinal cord injury
    Authors: Zachary T. Olmsted, Cinzia Stigliano, Annalisa Scimemi, Tatiana Wolfe, Jose Cibelli, Philip J. Horner et al.
    iScience
  3. Human-Induced Neural and Mesenchymal Stem Cell Therapy Combined with a Curcumin Nanoconjugate as a Spinal Cord Injury Treatment
    Authors: Pablo Bonilla, Joaquim Hernandez, Esther Giraldo, Miguel A. González-Pérez, Ana Alastrue-Agudo, Hoda Elkhenany et al.
    International Journal of Molecular Sciences
  4. Translocation of fibroblast growth factor-10 and its receptor into nuclei of human urothelial cells.
    Authors: Kosman J, Carmean N, Leaf EM, Dyamenahalli K, Bassuk JA
    J. Cell. Biochem., 2007-10-15;102(3):769-85.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  5. HPLC-Electrospray Ionization-Mass Spectrometry (LC-ESI-MS) Optimization by High-Performance Design of Experiments (DOE) for Astrocyte Glutamine Measurement
    Authors: Khaggeswar Bheemanapally, Mostafa M. H. Ibrahim, Karen P. Briski
    Journal of Mass Spectrometry
  6. FGF10 Signaling differences between type I pleuropulmonary blastoma and congenital cystic adenomatoid malformation
    Authors: Guillaume Lezmi, Virginie Verkarre, Naziha Khen-Dunlop, Shamila Vibhushan, Alice Hadchouel, Caroline Rambaud et al.
    Orphanet Journal of Rare Diseases
  7. Norepinephrine Regulation of Adrenergic Receptor Expression, 5' AMP-Activated Protein Kinase Activity, and Glycogen Metabolism and Mass in Male Versus Female Hypothalamic Primary Astrocyte Cultures
    Authors: Ibrahim MMH, Bheemanapally K, Sylvester PW, Briski KP.
    ASN Neuro
  8. Cerebellar Granule Cell Replenishment Post-Injury by Adaptive Reprogramming of Nestin+ Progenitors
    Authors: Alexandre Wojcinski, Andrew K. Lawton, N Sumru. Bayin, Zhimin Lao, Daniel N. Stephen, Alexandra L. Joyner
    Nature Neuroscience

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