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Human FCRL6/FcRH6 Antibody

Catalog #: MAB6745 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB6745
MAB6745-SP
Detection of FCRL6/FcRH6 in Human Peripheral Blood Lymphocytes by Flow Cytometry.
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Human FCRL6/FcRH6 Antibody Summary

Species Reactivity
Human
Specificity
Detects human FCRL6/FcRH6 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) FCRL1, rhFCRL2, rhFCRL3, rhFCRL4, rhFCRL5, rhFcRN, or rhFCRLB/FCRY is observed.
Source
Monoclonal Mouse IgG1 Clone # 672505
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
 Chinese hamster ovary cell line CHO-derived recombinant human FCRL6/FcRH6      
Lys16-Leu312
Accession # Q6DN72
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Flow Cytometry
2.5 µg/106 cells
See below
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of FCRL6/FcRH6 antibody in Human Peripheral Blood Lymphocytes antibody by Flow Cytometry. View Larger

Detection of FCRL6/FcRH6 in Human Peripheral Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human FCRL6/FcRH6 Monoclonal Antibody (Catalog # MAB6745) followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0101B) and Mouse Anti-Human NCAM-1/CD56 PE-conjugated Monoclonal Antibody (Catalog # FAB2408P). Quadrant markers were set based on control antibody staining (Catalog # MAB002).

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Sterile PBS to a final concentration of 0.5 mg/mL.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: FCRL6/FcRH6

FCRL6 (Fc receptor-like protein 6; also FcRH6 and IFGP6) is a 66 kDa member of the Ig Superfamily.  It is found on CD56dim CD16+ NK cells, CD56+ CD3+ NKT cells, gd T cells, and effector plus effector-memory CD8+ T cells.  FCRL6 is not a receptor for immunoglobulin.  It does, however, bind to isoforms of HLA-DR that are expressed on APCs.  Given that FCRL6 contains a cytoplasmic ITIM, FCRL6 may function as an inhibitory receptor for MHC Class II.  Mature human FCRL6 is a 415 amino acid (aa) type I transmembrane protein.  It contains a 288 aa extracellular region (aa 20-307) that shows three C2-type Ig-like domains (aa 20-293), and a 106 aa cytoplasmic domain.  There are multiple potential splice variants.  One shows a deletion of aa 105-200 accompanied by a 13 aa substitution for aa 394-434; a second possesses a 15 aa substitution for aa 383-434; and a third shows an alternative start site seven aa upstream of the standard site accompanied by a 13 aa substitution for aa 394-434.  Over aa 16-312, human FCRL6 shares only 33% aa identity with the mouse counterpart to FCRL6.

Long Name
Fc Receptor-like 6
Entrez Gene IDs
343413 (Human); 677296 (Mouse)
Alternate Names
Fc receptor-like 6; FcRH6; FCRL6; FLJ16056; IFGP6

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