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Human Daxx (NP_001341.1) VersaClone cDNA

Catalog #: RDC3692 Datasheet / COA / SDS
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RDC3692
Human Daxx (NP_001341.1) VersaClone cDNA
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Human Daxx (NP_001341.1) VersaClone cDNA Summary

Specifications

Source
N/A
Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Background: Daxx

Daxx (Fas death domain-associated-xx; also death domain-associated protein 6) is a ubiquitously expressed, proapoptotic protein that belongs to the Daxx family of molecules. Although it has a predicted MW of 81 kDa, it runs anomously at 110 kDa in SDS-PAGE. Daxx is found in the nucleus where it represses transcription. In the cytoplasm, it binds to ASK1, where it mediates Fas-induced apoptosis. Human Daxx is 740 amino acids (aa) in length and contains three coiled-coil regions (aa 180-217; 358-399; 430-489), two NLSs, and an Asp/Glu-rich acidic region (aa 434-572). One splice variant is known that shows a 15 aa substitution for aa 696-740. Human Daxx shares 71% and 90% aa identity with mouse and dog Daxx, respectively.

Long Name
Fas Death Domain-associated Protein
Entrez Gene IDs
1616 (Human); 13163 (Mouse); 140926 (Rat)
Alternate Names
BING2; CENP-C binding protein; DAP6; DAP6MGC126245; Daxx; death domain-associated protein 6; death-associated protein 6; death-domain associated protein; EAP1; ETS1-associated protein 1; Fas death domain-associated protein; Fas-binding protein; hDaxx; MGC126246

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