Human CIDEA Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: CIDEA

CIDEA (Cell death-Inducing DNA fragmentation factor-alpha -like Effector A) is a 24-27 kDa member of the CIDE family of molecules. It is expressed in human adipocytes and striated muscle, plus mouse brown adipocytes and hepatocytes, and appears to have at least two functions. In the cytoplasm of fat cells, CIDEA localizes to lipid droplets and ER, and promotes the formation of lipid droplets at the expense of lipolysis and AMPK activity. In the nucleus, CIDEA apparently binds to LXR, and is capable of inducing apoptosis. CIDEA undergoes O-linked glycosylation. When glycosylated, CIDEA is nuclear; when nonglycosylated, CIDEA is cytoplasmic. Human CIDEA is 219 amino acids (aa) in length, and contains one CIDE domain (aa 33-110) that potentially mediates dimerization. CIDEA reportedly homodimerizes, and heterodimerizes with CIDEB. There is one potential isoform variant that possesses a 46 aa substitution for aa 1-12. Over aa 61-162, human CIDEA shares 89% aa identity with mouse CIDEA.

Product Datasheets

Related Research Areas

• Adaptor Proteins
• Adaptor Proteins in the Akt Pathway
• Adipogenesis Markers
• Apoptosis Adaptor Proteins
• Diabetes
• Inhibitors of Apoptosis (IAPs) and Regulators
• Obesity