Human Caveolin-1 (NP_001744) VersaClone cDNA

Human Caveolin-1 (NP_001744) VersaClone cDNA Summary

Specifications

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Background: Caveolin-1

Caveolin-1 is a palmitoylated 22 kDa membrane-associated protein in caveolae which are cholesterol-rich invaginations in the plasma membrane involved in vesicular transport and the regulation of lipid rafts and signal transduction. Caveolin-1 expression is dysregulated during cancer progression and exhibits both positive and negative effects on tumor progression. The central region of Caveolin-1 (aa 105 - 125) is buried in the lipid layer, while the N- and C-terminal flanking regions are exposed to the cytoplasm and interact with many other proteins. Alternate splicing in human, mouse, and rat generates an isoform with a deletion of the N-terminal 31 residues.

Related Research Areas

• Actin Stress Fibers and Focal Adhesions During EMT
• Cancer Biomarkers
• Cell to Cell Adhesion Disassembly During EMT
• Focal Adhesions
• Lipid and Fatty Acid Transport
• Muscle Stem Cell Markers
• Myogenesis Markers
• Myogenic Precursor Markers
• Phospholipases, Small GTPases, and Other Molecules in the Akt Pathway
• Uptake and Transport Molecules in VSMC
• Uptake and Transport Molecules on Endothelial Cells