human Agrin (NP_940978.2) VersaClone cDNA

Catalog # Availability Size / Price Qty
RDC3631
human Agrin (NP_940978.2) VersaClone cDNA
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human Agrin (NP_940978.2) VersaClone cDNA Summary

Specifications

Source
N/A
Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Background: Agrin

Agrin is a 400-600 kDa heparan sulfate proteoglycan component of the extracellular matrix. Multiple forms of are generated by alternative splicing and proteolytic cleavage. Agrin binds to BMP-2, BMP-4, and TGF-beta, and it blocks BMP-induced signaling through BMPR-IA. Agrin binds to a complex of alpha-Dystroglycan, MuSK, and LRP4 on myotubes and induces the clustering of AChR and motoneuron-myotube adhesion at the neuromuscular junction. It binds the Abeta (1-40) peptide in Alzheimer’s disease plaques, promotes amyloid fibril formation, and regulates neuronal excitability. It also binds the gp41 coat protein of HIV-1 and functions as an epithelial cell-virus attachment receptor. During T cell activation, Agrin contributes to formation of the immunological synapse and regulates the threshold of T cell activation. Agrin is upregulated in hepocellular carcinoma, where it enhances cell proliferation and tumor progression.

Entrez Gene IDs
375790 (Human); 11603 (Mouse); 25592 (Rat)
Alternate Names
agrin proteoglycan; Agrin; AGRN

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