Human ABCA1 (NP_005493) VersaClone cDNA Summary
Specifications
Product Datasheets
Background: ABCA1
ABCA1 (ATP-binding cassette, subfamily A member 1; also cholesterol efflux regulatory protein) is a 240-280 kDa member of the ABCA family, ABC transporter superfamily of molecules. Widely expressed, particularly by macrophages, ABCA1 participates in the transport of lipid across cell membranes. Once transported, ABCA1 is passed on to tethered ApoA-I to form HDL. Human ABCA1 is 2261 amino acids (aa) in length. It has up to 15 transmembrane segments with beginning and ending cytoplasmic domains and a large cytoplasmic central region. ABC transporters are found between aa 899-1311 and 1912-2144. Amino acids 2216-2221 are essential for lipid transport, and two intramolecular disulfide bonds are required for activity (Cys75-Cys309 and Cys1463/1465-Cys1477). There are three potential isoform variants of ABCA1. One possesses an alternative start site at Met61, while two others contain 12 aa and 123 aa substitutions for aa 241-2261, respectively. Over aa 1248-1350, human ABCA1 shares 97% aa identity with mouse ABCA1.
Citation for Human ABCA1 (NP_005493) VersaClone cDNA
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
-
ABCA1 Expression Is Upregulated in an EMT in Breast Cancer Cell Lines via MYC-Mediated De-Repression of Its Proximal Ebox Element
Authors: S Prijic, JT Chang
Biomedicines, 2022-03-02;10(3):. 2022-03-02
FAQs
No product specific FAQs exist for this product, however you may
View all cDNA Clone FAQsReviews for Human ABCA1 (NP_005493) VersaClone cDNA
There are currently no reviews for this product. Be the first to review Human ABCA1 (NP_005493) VersaClone cDNA and earn rewards!
Have you used Human ABCA1 (NP_005493) VersaClone cDNA?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image