HQL 79

Catalog #: 3530
2 Citations Datasheet / COA / SDS

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HQL 79 | CAS No. 162641-16-9 | Synthase/Synthetase Inhibitors

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Description: Human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor

Chemical Name: 4-(Diphenylmethoxy)-1-(3-2H-tetrazol-5-yl)propyl]-piperidine

Purity: ≥99%

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Product Details

Citations (2)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

HQL 79 is an orally active and specific inhibitor of human hematopoietic prostaglandin D synthase (H-PGDS) (IC₅₀ = 6 μM). Antiallergic and anti-inflammatory; displays antiasthmatic activity and potent antihistaminic properties in vivo.

Technical Data

M.Wt:

377.48

Formula:

C₂₂H₂₇N₅O

Solubility:

Soluble to 25 mM in DMSO

Purity:

≥99%

Storage:

Store at RT

CAS No:

162641-16-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase.
Aritake et al.
J.Biol.Chem., 2006;281:15277
Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antihistaminic effects.
Matsushita et al.
Jpn.J.Pharmacol., 1998;78:11
Prostaglandin D₂-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher.
Mohri et al.
J.Neurosci., 2006;26:4383

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Citations for HQL 79

The citations listed below are publications that use Tocris products. Selected citations for HQL 79 include:

2 Citations: Showing 1 - 2

Lipocalin-Like Prostaglandin D Synthase but Not Hemopoietic Prostaglandin D Synthase Deletion Causes Hypertension and Accelerates Thrombogenesis in Mice.
Authors: Song Et al.
J Pharmacol Exp Ther 2018;367:425
Prostaglandin D2 Regulates SOX9 Nuclear Translocation during Gonadal Sex Determination in Tammar Wallaby, Macropus eugenii.
Authors: Yu Et al.
Sex Dev 2017;11:143-150

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