Honokiol
Chemical Name: 5,3'-Diallyl-2,4'-dihydroxybiphenyl
Purity: ≥98%
Biological Activity
Honokiol is an anti-inflammatory, antioxidant, antitumor and antiangiogenic agent. Blocks NF-κB activation by a variety of stimuli, including TNF and okadaic acid. Shown to scavenge superoxide and peroxyl radicals. Also inhibits a variety of inflammatory responses. Reverses cardiac hypertrophy in mice via SIRT3 activation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana baillon: synthesis, quantification, and measurement of biological activities in vitro and in vivo.
Kitamura S, Morisseau C, Inceoglu B, Kamita S, De Nicola G, Nyegue M, Hammock B
PLoS ONE, 2015;10(2):e0117438. -
The small molecule mimetic agonist trimebutine of adhesion molecule L1 contributes to functional recovery after spinal cord injury in mice
J Xu, C Hu, Q Jiang, H Pan, H Shen, M Schachner
Dis Model Mech, 2017;0(0):. -
Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo.
Bai et al.
J.Biol.Chem., 2003;278:35501 -
Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression.
Kim and Cho
Acta Pharmacol.Sinica, 2008;29:113 -
Honokiol is a potent scavenger of superoxide and peroxyl radicals.
Dikalov et al.
Biochem.Pharmacol., 2008;76:589 -
Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-κB activation pathway.
Ahn et al.
Mol.Cancer Res., 2006;4:621
Product Datasheets
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Citations for Honokiol
The citations listed below are publications that use Tocris products. Selected citations for Honokiol include:
2 Citations: Showing 1 - 2
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Mitochondrial and Neuronal Dysfunctions in L1 Mutant Mice.
Authors: Melitta Et al.
Int J Mol Sci 2022;23
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Trimebutine, a small molecule mimetic agonist of adhesion molecule L1, contributes to functional recovery after spinal cord injury in mice.
Authors: Xu Et al.
Dis Model Mech 2017;10:1117
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