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HHP 9

Catalog #: 7828 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7828/5
HHP 9 | Active Degraders
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Description: BET bromodomain Degrader (PROTAC®); also potent Hedgehog pathway inhibitor

Chemical Name: 2-Methoxyethyl 4-(3-((1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

Purity: ≥98%

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Biological Activity

HHP 9 is a potent BET bromodomain Degrader (PROTAC®; DC50 values are 0.03 μM, 0.2 μM and 0.2 μM at BRD3, BRD2 and BRD4 respectively). BRD2, BRD3 and BRD4 are almost completely degraded by HHP 9 in vitro (after 27h incubation with 0.5 - 5 μM of HHP 9). Comprises a Hedgehog Pathway Inhibitor-1 (HPI-1, Cat. No. 3839) coupled to a CRBN ligand. BET bromodomain degradation through HPP-9 results in long-acting Hh pathway inhibition.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
900.99
Formula:
C49H52N6O11
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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