Home / Autotaxin Inhibitors / HA 130

HA 130

Catalog #: 4196
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4196/10
4196/50
HA 130 | CAS No. 1229652-21-4 | Autotaxin Inhibitors
1 Image
Description: Potent and selective autotaxin inhibitor

Chemical Name: B-[3-[[4-[[3-[(4-Fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-boronic acid

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

HA 130 is a potent and selective autotaxin inhibitor (IC50 = 28 nM). Binds and inhibits autotaxin reversibly. Displays no activity against the proteasome, recombinant NPP1 or alkaline phosphatase. Inhibits ATX-mediated cell migration in an A2058 melanoma cell assay.

Technical Data

M.Wt:
463.29
Formula:
C24H19BFNO5S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1229652-21-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Exocrine pancreatic carcinogenesis and autotaxin expression.
    Kadekar S, Silins I, Korhonen A, Dreij K, Al-Anati L, Hogberg J, Stenius U
    PLoS ONE, 2012;7(8):e43209.
  2. Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva
    K Hino, K Horigome, M Nishio, S Komura, S Nagata, C Zhao, Y Jin, K Kawakami, Y Yamada, A Ohta, J Toguchida, M Ikeya
    J. Clin. Invest., 2017;0(0):.
  3. Discovery and optimization of boronic acid based inhibitors of autotaxin.
    Albers et al.
    J.Med.Chem., 2010;53:4958
  4. Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation.
    Albers et al.
    Proc.Natl.Acad.Sci.USA, 2010;107:7257

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for HA 130

The citations listed below are publications that use Tocris products. Selected citations for HA 130 include:

2 Citations: Showing 1 - 2

  1. The Autotaxin-Lysophosphatidic Acid Axis Modulates Histone Acetylation and Gene Expression during Oligodendrocyte Differentiation.
    Authors: Wheeler Et al.
    J Neurosci  2015;35:11399
  2. Exocrine pancreatic carcinogenesis and autotaxin expression.
    Authors: Sandeep Et al.
    PLoS One  2012;7:e43209

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for HA 130

There are currently no reviews for this product. Be the first to review HA 130 and earn rewards!

Have you used HA 130?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.