GW 9508
Chemical Name: 4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid
Purity: ≥99%
Biological Activity
GW 9508 is a potent and selective agonist for the free fatty acid receptor FFA1 (GPR40) (pEC50 values are 7.32, < 4.3 and < 4.3 for FFA1, FFA2 and FFA3 receptors respectively). Inactive against a range of other GPCRs, kinases, proteases, integrins and PPARs. Potentiates glucose-stimulated insulin secretion in MIN6 cells (pEC50 = 6.14).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Functional analysis of free fatty acid receptor GPR120 in human eosinophils: implications in metabolic homeostasis.
Konno, Yasunori, Ueki, Shigehar, Takeda, Masahide, Kobayashi, Yoshiki, Tamaki, Mami, Moritoki, Yuki, Oyamada, Hajime, Itoga, Masamich, Kayaba, Hiroyuki, Omokawa, Ayumi, Hirokawa, Makoto
PLoS ONE, 2015;10(3):e0120386. -
EPA potentiates brown thermogenesis through FFAR4-dependent upregulation of miR-30b and miR-378
J Biol Chem, 2016;0(0):. -
Synthesis and activity of small molecule GPR40 agonists.
Garrido et al.
Bioorg.Med.Chem.Lett., 2006;16:1840 -
Pharmacological regulation of Ins secretion in MIN6 cells through fatty acid receptor GPR40: identification of agonist and antagonist small molecules.
Briscoe et al.
Br.J.Pharmacol., 2006;148:619 -
Activation of ATP-sensitive potassium channels in rat pancreatic β-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway.
Zhao and Chen
J.Endocrinol., 2008;198:533
Product Datasheets
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Citations for GW 9508
The citations listed below are publications that use Tocris products. Selected citations for GW 9508 include:
3 Citations: Showing 1 - 3
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Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation.
Authors: Dragano
J Neuroinflammation 2017;14(1):91
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Differential signaling by splice variants of the human free fatty acid receptor GPR120.
Authors: Watson Et al.
Mol Pharmacol 2012;81:631
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GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and Ins-sensitizing effects.
Authors: Oh Et al.
Cell 2010;142:687
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