Guanabenz acetate

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0885/100
Guanabenz acetate | CAS No. 23256-50-0 | Adrenergic alpha-2 Receptor Agonists
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Description: α2 agonist. Also I2 selective ligand

Chemical Name: [(2,6-Dichlorobenzylidene)amino]guanidine acetate

Purity: ≥98%

Product Details
Citations (5)
Supplemental Products
Reviews

Biological Activity

Guanabenz acetate is a α2-adrenergic agonist and IGRS (imidazoline I2 binding site) selective ligand.

Technical Data

M.Wt:
291.14
Formula:
C8H8Cl2N4.CH3CO2H
Solubility:
Soluble to 75 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
23256-50-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome.

    Proc Natl Acad Sci U S A, 2013;110(1):141-6.
  3. Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes.
    Nevin Z, Factor D, Karl R, Douvaras P, Laukka J, Windrem M, Goldman S, Fossati V, Hobson G, Tesar P
    Am J Hum Genet, 0;100(4):617-634.
  4. Guanabenz. A review of its pharmacodynamic properties and therapeutic efficacy in hypertension.
    Holmes et al.
    Drugs, 1983;26:212
  5. Are there multiple imidazoline binding sites?
    Michel and Insel
    Trends Pharmacol.Sci., 1989;10:342
  6. Renal effects of infusion of rilmenidine and guan. in conscious dogs: contribution of peripheral and central nervous system α2-adrenoceptors.
    Evans and Anderson
    Br.J.Pharmacol., 1995;116:1557

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Citations for Guanabenz acetate

The citations listed below are publications that use Tocris products. Selected citations for Guanabenz acetate include:

5 Citations: Showing 1 - 5

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