GSK 9027
Chemical Name: N-[4-[1-(4-Fluorophenyl)-1H-indazol-5-yl-3-(trifluoromethyl)phenyl]benzenesulfonamide
Purity: ≥98%
Biological Activity
GSK 9027 is a glucocorticoid receptor agonist (pIC50 = 8). Inhibits production of the proinflammatory mediator IL-6 in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Cytokine-induced loss of glucocorticoid function: effect of kinase inhibitors, long-acting beta(2)-adrenoceptor [corrected] agonist and glucocorticoid receptor ligands.
Rider C, Shah S, Miller-Larsson A, Giembycz M, Newton R
PLoS ONE, 2015;10(1):e0116773. -
Structure guided design of 5-arylindazole glucocorticoid receptor agonists and antagonists.
Yates et al.
J.Med.Chem., 2010;53:4531
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