Home / RIP Kinase Inhibitors / GSK 583

GSK 583

Catalog #: 6480
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6480/5
6480/25
GSK 583 | CAS No. 1346547-00-9 | RIP Kinase Inhibitors
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Description: Potent RIPK2 inhibitor; orally bioavailable and cell permeable

Chemical Name: 6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

GSK 583 is a potent RIPK2 inhibitor (IC50 values are 2 and 5 nM at rat and human kinases, respectively). Displays selectivity for RIP2K over p38α, VEGFR2 and a panel of 300 kinases. Exhibits some inhibition at BRK and Aurora A. Also displays similar binding affinity, but no detectable functional activity at RIP3. Active in vivo. Moderately orally bioavailable and cell permeable.

Technical Data

M.Wt:
398.45
Formula:
C20H19FN4O2S
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1346547-00-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for GSK 583

The citations listed below are publications that use Tocris products. Selected citations for GSK 583 include:

1 Citation: Showing 1 - 1

  1. Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets.
    Authors: Rui Et al.
    J Clin Invest  2021;131

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