GSK 4112
Chemical Name: 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
Purity: ≥98%
Biological Activity
GSK 4112 is a selective Rev-Erbα agonist (EC50 = 250 nM). Enhances recruitment of nuclear receptor co-repressor (NCoR) peptide to Rev-Erbα; causes acute suppression of Bmal1 gene transcription. Induces phase shifts in the circadian clock.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB.
Kojetin et al.
ACS Chem.Biol., 2011;6:131 -
Ligand modulation of REV-ERBα function resets the peripheral circadian clock in a phasic manner.
Meng et al.
J.Cell Science, 2008;121:3629
Product Datasheets
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Citations for GSK 4112
The citations listed below are publications that use Tocris products. Selected citations for GSK 4112 include:
4 Citations: Showing 1 - 4
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Circadian clock molecule REV-ERBα regulates lung fibrotic progression through collagen stabilization.
Authors: Isaac Kirubakaran Et al.
Nat Commun 2023;14:1295
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Sinapic Acid Ameliorates REV-ERB α Modulated Mitochondrial Fission against MPTP-Induced Parkinson's Disease Model.
Authors: Hyun Ok Et al.
Biomol Ther (Seoul) 2022;30:409-417
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Molecular clock REV-ERBα regulates cigarette smoke-induced pulmonary inflammation and epithelial-mesenchymal transition.
Authors: Irfan Et al.
JCI Insight 2021;6
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NR1D1 ameliorates Mycobacterium tuberculosis clearance through regulation of autophagy.
Authors: Chandra Et al.
Autophagy 2015;11:1987
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